2. Protein Tyrosine Kinase/RTK Apoptosis
  3. VEGFR Apoptosis
  4. Jolkinolide A

Jolkinolide A 是一种二萜类化合物，可从大戟属植物 (Euphorbia fischeriana Steud) 的根中提取。Jolkinolide A 具有抗肿瘤活性，通过影响肿瘤组织的血管生成。Jolkinolide A 可显著抑制 Akt-STAT3-mTOR 信号通路，降低 VEGF 在 A549 细胞中的表达。

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Jolkinolide A Chemical Structure

Jolkinolide A Chemical Structure

CAS No. : 37905-07-0

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Jolkinolide A 相关抗体

Top Publications Citing Use of Products

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells[1].

IC50 & Target

VEGF[1]
体外研究
(In Vitro)

Jolkinolide A (20-100 μg/mL; 24 h) 提高 A549 细胞中 caspase-9 蛋白水平[1]。
Jolkinolide A (40-80 μg/mL; 24 h) 降低 A549 细胞中 Akt-STAT3-mTOR 蛋白的表达[1]。
Jolkinolide A (20-100 μg/mL; 24 h) 抑制人脐静脉内皮细胞 (HUVEC) 增殖和迁移，促进细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Jolkinolide A 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 20 μg/mL, 40 μg/mL, 60 μg/mL, 80 μg/mL, and 100 μg/mL
Incubation Time: 24 hours
Result: Promoted caspase-9 protein expression in cells at 20-100 μg/mL. Inhibited expression levels of Akt, STAT3, and mTOR proteins in cells at 40-80 μg/mL.
体内研究
(In Vivo)

Jolkinolide A (40 mg/kg; 腹腔注射; 每 3 天一次，持续 2 个月) 抑制小鼠A549细胞异种移植瘤模型中VEGF蛋白的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice (4-5 weeks old) injected with A549 cells[1]
Dosage: 40 mg/kg
Administration: Intraperitoneal injection; once every 3 days for 2 months
Result: Significantly inhibited the expression of VEGF protein on the first, 10th, 30th, 45th, and 60th day of administration.
分子量

314.42

Formula

C20H26O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Jolkinolide A 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Jolkinolide A37905-07-0VEGFRApoptosisVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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