1. Epigenetics
  2. Histone Acetyltransferase
  3. KI-TOX-A3

KI-TOX-A3 是一种选择性蛋白质-蛋白质相互作用 (PPI) 抑制剂,靶向 TOX 蛋白 (对 TOX-KAT7 相互作用的 IC50 值为 0.51 μM)。KI-TOX-A3 诱导 TOX 的蛋白酶体降解,恢复 KAT7 介导的 H3K14 乙酰化,逆转 CD8+ T 细胞的衰竭,并抑制 T 细胞急性淋巴细胞白血病 (T-ALL) 细胞的增殖。KI-TOX-A3 有望用于血液系统肿瘤 (如 T-ALL) 的研究。

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KI-TOX-A3 Chemical Structure

KI-TOX-A3 Chemical Structure

CAS No. : 1351116-34-1

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生物活性

KI-TOX-A3 is a selective protein-protein interaction (PPI) inhibitor targeting TOX protein (with an IC50 value of 0.51 μM for TOX-KAT7 interaction). KI-TOX-A3 induces proteasomal degradation of TOX, restores KAT7-mediated H3K14 acetylation, reversing CD8+ T cell exhaustion and inhibiting T-cell acute lymphoblastic leukemia (T-ALL) cell proliferation. KI-TOX-A3 is promising for research of hematological tumors (e.g., T-ALL)[1].

分子量

319.31

Formula

C18H13N3O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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参考文献
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
KI-TOX-A3
目录号:
HY-176244
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