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  4. KN-92

KN-92 是 KN-93 的非活性衍生物，不具有 CaM 激酶抑制活性。KN-92 可作为对照化合物用于阐明KN-93的拮抗活性。KN-93 可渗透细胞，可逆和竞争性的 CaMKII 抑制剂。

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KN-92 Chemical Structure

KN-92 Chemical Structure

CAS No. : 176708-42-2

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规格 是否有货
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KN-92 的其他形式现货产品:

Other Forms of KN-92:

KN-92 相关抗体

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Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2].

体外研究
(In Vitro)

KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50 μM; 24 hours) is ineffective in blocking cell growth[2].
The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduces the expression of p53 and p21[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KN-92 相关抗体:

Cell Viability Assay[2]

Cell Line: Human hepatic stellate cells (LX-2)
Concentration: 5-50 μM
Incubation Time: 24 hours
Result: Ineffective in blocking cell growth.
分子量

456.98

Formula

C24H25ClN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KN-92 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KN-92176708-42-2KN92KN 92OthersinactivederivativeanalogcontrolexperimentalInhibitorinhibitorinhibit

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HY-15517
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