2. NF-κB Autophagy Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation
  3. Autophagy Keap1-Nrf2 p62 Apoptosis Reactive Oxygen Species (ROS) Caspase Bcl-2 Family
  4. L-Selenocystine

L-Selenocystine  (Synonyms: L-硒代胱氨酸)

目录号: HY-129960 纯度: ≥97.0%
COA 产品使用指南 技术支持

L-Selenocystine 是一种含硒的氨基酸。L-Selenocystine 具有氧化还原的性质。L-Selenocystine 对多种肿瘤细胞具有细胞毒性，可诱导 ROS 产生和细胞凋亡 (apoptosis)。此外，L-Selenocystine 可阻断 Nrf2 和自噬 (autophagy) 通路。L-Selenocystine 具有抗肿瘤的活性。

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Custom Peptide Synthesis

L-Selenocystine Chemical Structure

L-Selenocystine Chemical Structure

CAS No. : 29621-88-3

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规格 价格 是否有货 数量
25 mg ￥440
In-stock
50 mg ￥621
In-stock
100 mg ￥895
In-stock
250 mg ￥1700
In-stock
500 mg   询价  
1 g   询价  

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Customer Review

Other Forms of L-Selenocystine:

L-Selenocystine 相关抗体

Top Publications Citing Use of Products

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-Selenocystine is a selenium-containing amino acid. L-Selenocystine has redox properties. L-Selenocystine is cytotoxic to various tumor cells and can induce the production of ROS and apoptosis. L-Selenocystine can block the Nrf2 and autophagy pathways. L-Selenocystine has anti-tumor activity[1][2][3][4].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
3.6 μM
Compound: 1
Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anticancer activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 34217061]
CNE-2 IC50
5.6 μM
Compound: 1
Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anticancer activity against human CNE-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 34217061]
HL-60 IC50
34.5 μM
Compound: 1
Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anticancer activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 34217061]
SW-620 IC50
7.3 μM
Compound: 1
Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anticancer activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 34217061]
体外研究
(In Vitro)

L-Selenocystine (8-32 μM; 24 小时) 可抑制 HepG2 细胞增殖 (IC50: 5.444 μM)，诱导 ROS 产生和细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-Selenocystine 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2
Concentration: 8, 16, 32 μM
Incubation Time: 24 h
Result: Significantly inhibited HepG2 cell growth with increasing concentration.

Western Blot Analysis[1]

Cell Line: HepG2
Concentration: 8, 16, 32 μM
Incubation Time: /
Result: Inhibited the levels of Bid, Bax, Cleaved Caspase-9, Cleaved Caspase-3 and Cleaved PARP.
Reduced the levels of Bcl2.
分子量

334.09

同用名

L-硒代胱氨酸

Formula

C6H12N2O4Se2
CAS 号
性状

固体

颜色

Light yellow to brown

中文名称

L-硒代胱氨酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

H2O 中的溶解度 : 5.88 mg/mL (17.60 mM; ultrasonic and warming and adjust pH to 1 with HCl and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9932 mL 14.9660 mL 29.9321 mL
5 mM 0.5986 mL 2.9932 mL 5.9864 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥97.0%

COA (282 KB) HNMR (130 KB) LCMS (258 KB)

产品使用指南 (1538 KB)
参考文献

L-Selenocystine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.9932 mL 14.9660 mL 29.9321 mL 74.8301 mL
5 mM 0.5986 mL 2.9932 mL 5.9864 mL 14.9660 mL
10 mM 0.2993 mL 1.4966 mL 2.9932 mL 7.4830 mL
15 mM 0.1995 mL 0.9977 mL 1.9955 mL 4.9887 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Selenocystine29621-88-3L-硒代胱氨酸AutophagyKeap1-Nrf2p62ApoptosisReactive Oxygen Species (ROS)CaspaseBcl-2 FamilySequestosome-1SQSTM1anti-oxidantpro-oxidantamino acid ERcancerHeLaHepG2Inhibitorinhibitorinhibit

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