2. Others Neuronal Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Membrane Transporter/Ion Channel
  3. Isotope-Labeled Compounds Serotonin Transporter Trk Receptor PI3K mTOR P-glycoprotein Akt
  4. Levomilnacipran-d10 hydrochloride

Levomilnacipran-d10 hydrochloride  (Synonyms: (1S,2R)-Milnacipran-d10 hydrochloride; F2695-d10 hydrochloride)

目录号: HY-14794AS
产品使用指南 技术支持

Levomilnacipran-d10 ((1S,2R)-Milnacipran-d10) hydrochloride 是氘代标记的 Levomilnacipran hydrochloride (HY-B0168B)。Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride 是 Milnacipran (HY-B0168) 的对映异构体，也是能透过血脑屏障的 P-gp 强底物。Levomilnacipran hydrochloride 是 5-羟色胺和去甲肾上腺素再摄取抑制剂，对人去甲肾上腺素转运体 (NET) 和 5-羟色胺转运体 (SERT) 的 IC50 分别为 10.5 nM 和 19.0 nM，Ki 分别为 92.2 nM 和 1.2 nM。Levomilnacipran hydrochloride 具有抗抑郁与抗焦虑活性。Levomilnacipran hydrochloride 可用于抑郁症的研究。

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Levomilnacipran-d<sub>10</sub> hydrochloride Chemical Structure

Levomilnacipran-d10 hydrochloride Chemical Structure

CAS No. : 2747914-23-2

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Levomilnacipran-d10 hydrochloride 相关抗体

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  • 生物活性

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生物活性

Levomilnacipran-d10 ((1S,2R)-Milnacipran-d10) hydrochloride is deuterium labeled Levomilnacipran hydrochloride (HY-B0168B). Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC50 values of 10.5 nM and 19.0 nM, and Ki values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression[1][2].

分子量

292.87

同用名

(1S,2R)-Milnacipran-d10 hydrochloride; F2695-d10 hydrochloride

Formula

C15H13D10ClN2O
CAS 号
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Levomilnacipran-d10 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Levomilnacipran-d102747914-23-2(1S,2R)-Milnacipran-d10F2695-d10Isotope-Labeled CompoundsSerotonin TransporterTrk ReceptorPI3KmTORP-glycoproteinAkt5-HTTSERTSLC6A4Tropomyosin related kinase receptor Phosphoinositide 3-kinaseMammalian target of RapamycinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243PKBProtein kinase BInhibitorinhibitorinhibit

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