2. Apoptosis
  3. Apoptosis
  4. Lexatumumab

Lexatumumab  (Synonyms: HGS-ETR 2; ETR2-ST01)

目录号: HY-P99299 纯度: 96.95%
COA

摩尔计算器

Lexatumumab (HGS-ETR 2) 是一种人源激动 TRAIL 受体 2 (TRAIL-R2, DR5, APO-2) IgG1 型单克隆抗体。Lexatumumab 在恶性间皮瘤中诱导细胞凋亡 (apoptosis)。Lexatumumab 可用于恶性胸膜间皮瘤 (MPM) 研究。

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Lexatumumab Chemical Structure

Lexatumumab Chemical Structure

CAS No. : 845816-02-6

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7800
In-stock
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Lexatumumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lexatumumab (HGS-ETR 2) is a human agonistic TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research[1].

IC50 & Target

TRAIL-R2[1]
体外研究
(In Vitro)

Lexatumumab 与顺铂 Cisplatin (HY-17394) 联合可协同抑制细胞生长和增强凋亡死亡[1]。
Lexatumumab (0-10 µg/ml, 72 h) 在不同的黑色素瘤细胞系中诱导不同程度的细胞死亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lexatumumab 相关抗体:

Cell Viability Assay[2]

Cell Line: Melanoma cell lines
Concentration: 0.01, 0.1, 1.0 and 10.0 µg/ml
Incubation Time: 72 h
Result: Induced various degrees of cell death in the different cell lines.
体内研究
(In Vivo)

Lexatumumab (10mg/kg，静脉注射，每周两次)联合 Dacarbazine (HY-B0078) 可增加小鼠体内抗肿瘤效果[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FEMX-1 xenografts mice[2]
Dosage: 10 mg/kg, 10 mg/kg+Dacarbazine (62.5 mg/kg once a week, i.p. injection)
Administration: i.v., twice a week
Result: Increased antitumor effect in vivo when combined with Dacarbazine (HY-B0078). Induced cleavage of livin into its truncated, proapoptotic form, a compound previously shown to accelerate apoptosis.
Clinical Trial
分子量

143.6 (kDa)

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lexatumumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lexatumumab845816-02-6HGS-ETR 2 ETR2-ST01Apoptosismalignant pleural mesotheliomaMPM cellH2052SPC212H226FEMX-1 cellsanticancerInhibitorinhibitorinhibit

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