2. Apoptosis PI3K/Akt/mTOR Stem Cell/Wnt Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Apoptosis GSK-3 MMP Reactive Oxygen Species (ROS)
  4. LQB-118

LQB-118 是一种具有口服活性的紫檀醌。LQB-118 可以抑制胶质母细胞瘤细胞的迁移并诱导细胞死亡。LQB-118 可以通过调节 AKT/GSK3β 通路和 MMP-9/reck 基因表达来抑制前列腺癌细胞的迁移和侵袭。LQB 118 可以在体内外抑制酵母聚糖引发的炎症。LQB-118 可以在 Leishmania amazonensis 中选择性诱导 ROS 触发和线粒体依赖性的细胞凋亡 (apoptosis)。LQB-118 可用于炎症、感染和肿瘤疾病的研究。

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LQB-118

LQB-118 Chemical Structure

CAS No. : 1219104-20-7

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LQB-118 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases[1][2][3][4].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
11.21 μM
Compound: 5a
Growth inhibition of human A549 cells after 72 hrs by MTT assay
Growth inhibition of human A549 cells after 72 hrs by MTT assay
[PMID: 20117936]
Daudi IC50
3.1 μM
Compound: 5a
Growth inhibition of human Daudi cells after 24 to 72 hrs by MTT assay
Growth inhibition of human Daudi cells after 24 to 72 hrs by MTT assay
[PMID: 20117936]
HCT-8 IC50
2.6 μM
Compound: (+/-)-1a
Antineoplastic activity against human HCT8 cells after 72 hrs by MTT assay
Antineoplastic activity against human HCT8 cells after 72 hrs by MTT assay
[PMID: 22000949]
HL-60 IC50
1.3 μM
Compound: (+/-)-1a
Antineoplastic activity against human HL60 cells after 72 hrs by MTT assay
Antineoplastic activity against human HL60 cells after 72 hrs by MTT assay
[PMID: 22000949]
HL-60 IC50
2 μM
Compound: 5a
Growth inhibition of human HL60 cells after 72 hrs by MTT assay
Growth inhibition of human HL60 cells after 72 hrs by MTT assay
[PMID: 20117936]
J774 IC50
12.7 μM
Compound: (+/-)-1a
Selectivity index, ratio of IC50 for mouse J774 cells to IC50 for Leishmania amazonensis amastigotes infected in BALB/c mouse macrophages
Selectivity index, ratio of IC50 for mouse J774 cells to IC50 for Leishmania amazonensis amastigotes infected in BALB/c mouse macrophages
[PMID: 22000949]
J774 IC50
18.5 μM
Compound: (+/-)-1a
Cytotoxicity against mouse J774 cells after 72 hrs by MTT assay
Cytotoxicity against mouse J774 cells after 72 hrs by MTT assay
[PMID: 22000949]
Jurkat IC50
6.77 μM
Compound: 5a
Growth inhibition of human Jurkat cells after 24 to 72 hrs by MTT assay
Growth inhibition of human Jurkat cells after 24 to 72 hrs by MTT assay
[PMID: 20117936]
K562 IC50
1.67 μM
Compound: (+/-)-1a
Antineoplastic activity against human K562 cells after 72 hrs by MTT assay
Antineoplastic activity against human K562 cells after 72 hrs by MTT assay
[PMID: 22000949]
K562 IC50
1.67 μM
Compound: 5a
Growth inhibition of human K562 cells after 24 to 72 hrs by MTT assay
Growth inhibition of human K562 cells after 24 to 72 hrs by MTT assay
[PMID: 20117936]
K562-Lucena 1 IC50
2.75 μM
Compound: 5a
Growth inhibition of human K562-Lucena 1 cells after 24 to 72 hrs by MTT assay
Growth inhibition of human K562-Lucena 1 cells after 24 to 72 hrs by MTT assay
[PMID: 20117936]
LNCaP IC50
1.1 μg/mL
Compound: LQB-118, LQB
Cytotoxicity against human LNCAP cells assessed as inhibition of cell viability after 48 hrs by MTT assay
Cytotoxicity against human LNCAP cells assessed as inhibition of cell viability after 48 hrs by MTT assay
[PMID: 24794748]
MDA-MB-435 IC50
2.3 μM
Compound: (+/-)-1a
Antineoplastic activity against human MDA-MB-435 cells after 72 hrs by MTT assay
Antineoplastic activity against human MDA-MB-435 cells after 72 hrs by MTT assay
[PMID: 22000949]
NCI-H460 IC50
12.86 μM
Compound: 5a
Growth inhibition of human H460 cells after 72 hrs by MTT assay
Growth inhibition of human H460 cells after 72 hrs by MTT assay
[PMID: 20117936]
PBMC IC50
> 20 μM
Compound: (+/-)-1a
Cytotoxicity against PHA activated human PBMC cells after 72 hrs by MTT assay
Cytotoxicity against PHA activated human PBMC cells after 72 hrs by MTT assay
[PMID: 22000949]
PBMC IC50
> 20 μM
Compound: 5a
Growth inhibition of phytohemagglutinin-activated human PBMC cells after 24 to 72 hrs by MTT assay
Growth inhibition of phytohemagglutinin-activated human PBMC cells after 24 to 72 hrs by MTT assay
[PMID: 20117936]
PC-3 IC50
1.7 μg/mL
Compound: LQB-118, LQB
Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 48 hrs by MTT assay
[PMID: 24794748]
RWPE-1 IC50
1.3 μg/mL
Compound: LQB-118, LQB
Cytotoxicity against human RWPE1 cells assessed as inhibition of cell viability after 48 hrs by MTT assay
Cytotoxicity against human RWPE1 cells assessed as inhibition of cell viability after 48 hrs by MTT assay
[PMID: 24794748]
Raji IC50
3.32 μM
Compound: 5a
Growth inhibition of human Raji cells after 24 to 72 hrs by MTT assay
Growth inhibition of human Raji cells after 24 to 72 hrs by MTT assay
[PMID: 20117936]
SF-295 IC50
3.6 μM
Compound: (+/-)-1a
Antineoplastic activity against human SF295 cells after 72 hrs by MTT assay
Antineoplastic activity against human SF295 cells after 72 hrs by MTT assay
[PMID: 22000949]
分子量

304.30

Formula

C19H12O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LQB-118 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LQB-1181219104-20-7LQB118LQB 118ApoptosisGSK-3MMPReactive Oxygen Species (ROS)Glycogen synthase kinase-3Glycogen synthase kinase 3Matrix metalloproteinasesAKT/GSK3βMMP-9/reckapoptosisinflammationtumorInhibitorinhibitorinhibit

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