1. Immunology/Inflammation
  2. Interleukin Related
  3. Lusvertikimab

Lusvertikimab  (Synonyms: 芦维奇单抗; OSE-127)

目录号: HY-P99412 纯度: 99.41%
COA

Lusvertikimab (OSE-127) 是一种人源化 IL7R 单克隆抗体。Lusvertikimab 不会被靶细胞内化并阻止 IL7R 异二聚化和随后的下游信号传导。Lusvertikimab 具有抗白血病功效,具有用于 B 细胞前体急性淋巴细胞白血病 (BCP-ALL) 研究的潜力。

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Lusvertikimab Chemical Structure

Lusvertikimab Chemical Structure

CAS No. : 2375835-91-7

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lusvertikimab (OSE-127) is a humanized IL7R monoclonal antibody. Lusvertikimab is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research[1].

IC50 & Target[1]

IL7R

 

体外研究
(In Vitro)

OSE-127 (4 天) 可阻断 IL7 依赖性 ALL 细胞系和患者来源的异种移植 (PDX) 样本中的 STAT5 磷酸化[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

当相应的对照小鼠显示出明显白血病的临床症状时,OSE-127 处理的小鼠体内 21/22 (95%) PDX 样本显示外周血 (PB) 母细胞减少[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

芦维奇单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Lusvertikimab 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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