1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. Magnesium citrate

Magnesium citrate  (Synonyms: Trimagnesium dicitrate)

目录号: HY-W105835 纯度: 98.0%
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Magnesium citrate (Trimagnesium dicitrate) 是一种能透过血脑屏障且口服有效的含镁化合物。Magnesium citrate 能作为肠道清洁剂,用于泻药的研究。Magnesium citrate 也能提高疼痛阈值,用于止痛方面的研究。

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Magnesium citrate

Magnesium citrate Chemical Structure

CAS No. : 3344-18-1

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100 mg ¥210
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500 mg ¥350
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查看 Toll-like Receptor (TLR) 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Magnesium citrate (Trimagnesium dicitrate) is an orally active magnesium-containing compound that can cross the blood-brain barrier (BBB). Magnesium citrate can be used as an intestinal cleanser and is studied for its application in laxatives. Magnesium citrate can also increase the pain threshold and is studied for pain-relief purposes[1][2].

IC50 & Target[1]

TLR4

 

体内研究
(In Vivo)

Magnesium citrate (66 mg/kg; 灌胃; 单剂量) 在小鼠中可以提高疼痛阈值[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb-c mice[1]
Dosage: 66 mg/kg
Administration: Oral gavage; single dose
Result: Increased the pain threshold of mice, especially 4 hours after administration.
Decreased motor conduction velocity decreased in the early stage (4-8 hours) and then increased at 24 hours.
Decreased forelimb grip strength at 4, 8, and 24 hours.
Increased locomotor activity at 4 and 8 hours in the open-field test.
Decreased TLR4 expression in the brain, increased TLR4 expression in the sciatic nerve, and caused no significant change in the dorsal root ganglia and muscle tissue.
分子量

451.11

Formula

C12H10Mg3O14

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

H2O 中的溶解度 : 4.72 mg/mL (10.46 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2168 mL 11.0838 mL 22.1675 mL
5 mM 0.4434 mL 2.2168 mL 4.4335 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.2168 mL 11.0838 mL 22.1675 mL 55.4189 mL
5 mM 0.4434 mL 2.2168 mL 4.4335 mL 11.0838 mL
10 mM 0.2217 mL 1.1084 mL 2.2168 mL 5.5419 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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