2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Maresin 1

Maresin 1 是人体内源性的 DHA 产生的 特异性调节介质，可以刺激胞内Ca2+ 产生和分泌。Maresin 1 具有抗炎活性。

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Maresin 1 Chemical Structure

Maresin 1 Chemical Structure

CAS No. : 1268720-28-0

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规格 价格 是否有货 数量
10 μg (277.4 µM * 100 μL in Ethanol) ￥2500
In-stock
25 μg (277.4 µM * 250 μL in Ethanol) ￥5000
In-stock

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Customer Review

Other Forms of Maresin 1:

Maresin 1 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].

体外研究
(In Vitro)

Maresin 1 (MaR1，300 nM) 除了减少 IL-1β、TNF-α、IL-6 和 INF-γ 的产生外，还能减少中性粒细胞迁移和活性氧的产生[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Maresin 1 相关抗体:

Cell Viability Assay[3]

Cell Line: Neutrophils (2 ╳105 cells/well).
Concentration: 300 nM.
Incubation Time: 30 min.
Result: Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well[3].
体内研究
(In Vivo)

Maresin 1 (MaR1) 以剂量依赖性方式抑制神经元中的 TRPV1 电流，阻断辣椒素 (100 nM) 诱导的内向电流 (IC50=0.49 nM)，并减轻炎症和化疗引起的神经性疼痛在小鼠中[2]。
Maresin 1 (MaR1、0.1、0.3 和 1 μg/动物，ev) 保护小鼠免受急性 DSS 诱导的结肠炎。Maresin 1 (0.3 和 1 μg/动物，ev) 处理显著减少 DSS 诱导的结肠炎急性方案中的宏观损伤[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD1 mice (8-10 wk of age) (colitis was induced by DSS)[3].
Dosage: 0.1, 0.3, and 1 μg/animal.
Administration: Intraocular route once a day from day 0 to day 7.
Result: MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue.
分子量

360.49

Formula

C22H32O4
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: ≥99.0%

COA (183 KB)

产品使用指南 (1538 KB)
参考文献

Maresin 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Maresin 11268720-28-0Maresin1Maresin-1Reactive Oxygen SpeciesROSLPSCa2+Inhibitorinhibitorinhibit

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目录号：
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