2. Academic Validation
  3. BN 80927: a novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II

BN 80927: a novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II

  • Bioorg Med Chem Lett. 1999 Sep 6;9(17):2599-602. doi: 10.1016/s0960-894x(99)00428-x.
O Lavergne 1,  J Harnett,  A Rolland,  C Lanco,  L Lesueur-Ginot,  D Demarquay,  M Huchet,  H Coulomb,  D C Bigg
Affiliations

Affiliation

  • 1 Institut Henri Beaufour, Les Ulis, France.
PMID: 10498216 DOI: 10.1016/s0960-894x(99)00428-x
Abstract

BN 80927, a novel homocamptothecin derivative, inhibits both Topoisomerase I and Topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines.

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