2. Academic Validation
  3. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens

Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens

  • Bioorg Med Chem. 2007 May 15;15(10):3445-9. doi: 10.1016/j.bmc.2007.03.011.
Seizo Sato 1,  Jiro Takeo,  Chihiro Aoyama,  Hiroyuki Kawahara
Affiliations

Affiliation

  • 1 Central Research Laboratory, Nippon Suisan Kaisha, Ltd, 559-6 Kitano-machi, Hachioji, Tokyo 192-0906, Japan. s-satou@nissui.co.jp
PMID: 17374486 DOI: 10.1016/j.bmc.2007.03.011
Abstract

The methanol extract of Sophora flavescens, which is used in traditional Chinese medicine (sophorae radix), showed potent Na(+)-glucose cotransporter (SGLT) inhibitory activity. Our search for active components identified many well-known flavonoid antioxidants: kurarinone, sophoraflavanone G, kushenol K, and kushenol N.

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