2. Academic Validation
  3. Substituted dithiazole piperazine benzamides as novel amyloid beta peptide reducing agents

Substituted dithiazole piperazine benzamides as novel amyloid beta peptide reducing agents

  • Bioorg Med Chem Lett. 2014 Sep 15;24(18):4384-4388. doi: 10.1016/j.bmcl.2014.08.022.
Hongjie Wang 1,  Ruizhi Wang 1,  Madepalli K Lakshmana 1,  Adel Nefzi 2
Affiliations

Affiliations

  • 1 Torrey Pines Institute for Molecular Studies, Port Saint Lucie, FL 34987, United States.
  • 2 Torrey Pines Institute for Molecular Studies, Port Saint Lucie, FL 34987, United States. Electronic address: adeln@tpims.org.
PMID: 25155386 DOI: 10.1016/j.bmcl.2014.08.022
Abstract

Alzheimer's disease is a persistent neurodegenerative disorder of elderly characterized clinically by irreversible loss of memory due to accumulation of amyloid beta peptides within the amyloid plaques. We report the parallel synthesis and screening results of diverse substituted di-thiazole piperazine benzamides. A new compound TPI-1917-49 was identified as a promising amyloid reducing agent by lowering the levels of Aβ at least in two cell types and in vivo.

Keywords

Alzheimer’s disease; Amyloid reducing agent; Parallel synthesis; Thiazole.

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