2. Neuronal Signaling
  3. Amyloid-β
  4. TPI-1917-49

TPI-1917-49 是一种可通过血脑屏障的淀粉样 β (Aβ) 减少剂。TPI-1917-49 通过促进淀粉样前体蛋白 (APP) 的非淀粉样生成途径 (增加 α-分泌酶介导的 sAPPα 生成)，减少 Aβ 肽段的产生。TPI-1917-49 在小鼠模型中减少淀粉样板块。TPI-1917-49 可用于阿尔茨海默症研究。

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TPI-1917-49

TPI-1917-49 Chemical Structure

CAS No. : 1250849-11-6

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TPI-1917-49 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TPI-1917-49 is an agent that can cross the blood-brain barrier and reduce amyloid β (Aβ). TPI-1917-49 reduces the production of Aβ peptide segments by promoting the non-amyloidogenic pathway of amyloid precursor protein (APP) (increasing the generation of sAPPα mediated by α-secretase). TPI-1917-49 reduces amyloid plaques in mouse models. TPI-1917-49 can be used in Alzheimer's disease research[1].

分子量

570.69

Formula

C29H26N6O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TPI-1917-49 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPI-1917-491250849-11-6Amyloid-ββ-amyloid peptideAβAbetaamyloid beta (Aβ) reductionnon-amyloidogenic pathwayalpha-secretasesAPPαAlzheimer's diseasethiazole derivativeAPP processingInhibitorinhibitorinhibit

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产品名称：
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目录号：
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