2. Academic Validation
  3. Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry

Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry

  • R Soc Open Sci. 2021 Mar 31;8(3):201703. doi: 10.1098/rsos.201703.
C Johnston 1,  C Hardacre 2,  M E Migaud 1 3
Affiliations

Affiliations

  • 1 School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Northern Ireland, UK.
  • 2 The Mill, Sackville Street Campus, University of Manchester, Manchester, UK.
  • 3 Department of Pharmacology, Mitchell Cancer Institute, 1660 Spring Hill Avenue, Mobile, AL, USA.
PMID: 34035937 DOI: 10.1098/rsos.201703
Abstract

Liquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5'-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic Solvents, the facilitation of mechanochemical reactions through the improved mixing of solid reagents, and low hydrolytic product formation.

Keywords

dinucleotides; mechanochemistry; organophosphorus.

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