2. Academic Validation
  3. The novel antifungal agent AB-22 displays in vitro activity against hyphal growth and biofilm formation in Candida albicans and potency for treating systemic candidiasis

The novel antifungal agent AB-22 displays in vitro activity against hyphal growth and biofilm formation in Candida albicans and potency for treating systemic candidiasis

  • J Microbiol. 2022 Apr;60(4):438-443. doi: 10.1007/s12275-022-2016-0.
Kyung-Tae Lee 1,  Dong-Gi Lee 2,  Ji Won Choi 3 4,  Jong-Hyun Park 3 4,  Ki Duk Park 3 4,  Jong-Seung Lee 5,  Yong-Sun Bahn 6
Affiliations

Affiliations

  • 1 Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
  • 2 AmtixBio Co., Ltd., Hanam, 12925, Republic of Korea.
  • 3 Brain Science Institute, Korea Institute of Science & Technology (KIST), Seoul, 02792, Republic of Korea.
  • 4 Division of Bio-Med Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea.
  • 5 AmtixBio Co., Ltd., Hanam, 12925, Republic of Korea. jason_lee@amtixbio.com.
  • 6 Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea. ysbahn@yonsei.ac.kr.
PMID: 35286605 DOI: 10.1007/s12275-022-2016-0
Abstract

Systemic candidiasis, which is mainly caused by Candida albicans, is a serious acute fungal Infection in the clinical setting. In a previous study, we reported that compound 22h (designated as AB-22 in this study), a vinyl sulfate compound, is a fast-acting fungicidal agent against a broad spectrum of Fungal pathogens. In this study, we aimed to further analyze the in vitro and in vivo efficacy of AB-22 against filamentation, biofilm formation, and virulence of C. albicans. Under in vitro hyphal growth-inducing condition, AB-22 effectively inhibited germ tube formation and hyphal growth, which are required for the initiation of biofilm formation. Indeed, AB-22 significantly suppressed C. albicans biofilm formation in a dose-dependent manner. Moreover, AB-22 treatment inhibited the normal induction of ALS3, HWP1, and ECE1, which are all required for hyphal transition in C. albicans. Furthermore, AB-22 treatment increased the survival of mice systemically infected with C. albicans. In conclusion, in addition to its fungicidal activity, AB-22 inhibits filamentation and biofilm formation in C. albicans, which could collectively contribute to its potent in vivo efficacy against systemic candidiasis.

Keywords

antifungal drug efficacy; biofilm; systemic candidiasis.

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