2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Acetolactate Synthase (ALS) Endothelin-Converting Enzyme (ECE)
  4. AB-22

AB-22 是一种乙烯基硫酸盐化合物，是一种具有口服活性的抗真菌剂。AB-22 通过抑制白色念珠菌 (Candida albicans) SC5314 细胞中 ALS3、HWP1 和 ECE1 基因的表达，抑制菌丝生长和生物膜形成。AB-22 可用于感染的研究，如系统性念珠菌病。

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AB-22

AB-22 Chemical Structure

CAS No. : 1463913-43-0

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AB-22 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AB-22, a vinyl sulfate compound, is an orally active antifungal agent. AB-22 inhibits hyphal growth and biofilm initiation by inhibiting the gene expression of ALS3, HWP1, and ECE1 in Candida albicans SC5314 cells. AB-22 can be used for the research of infrction, such as systemic candidiasis[1].
体外研究
(In Vitro)

AB-22 (4 μg/mL；30-120 分钟) 延迟白念珠菌 SC5314 细胞芽管形成[1]。
AB-22 (0.25-3 小时) 通过抑制白色念珠菌 SC5314 细胞中 ALS3、HWP1 和 ECE1 的基因表达，抑制了菌丝生长和生物膜的起始[1]。
AB-22 (0.5-4 μg/mL；24 小时) 抑制白色念珠菌 SC5314 细胞菌丝生长[1]。
AB-22 (0.5-4 μg/mL；24 小时) 抑制白色念珠菌 SC5314 细胞生物膜形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AB-22 相关抗体:
体内研究
(In Vivo)

AB-22 (20-30 mg/kg，每日两次，连续 5 天，或 300 mg/kg，单次给药；口服) 可提高感染 C. albicans ATCC90028 细胞的 ICR 小鼠的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice infected with C. albicans ATCC90028 cells (male, 7-weeks-old)[1]
Dosage: 20 and 30 mg/kg, twice a day for 5 days or 300 mg/kg for a single dose
Administration: Orally administration
Result: Prolonged survival time and increased survival rate.
分子量

475.97

Formula

C22H30ClN7O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AB-22 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AB-221463913-43-0AB22AB 22FungalAcetolactate Synthase (ALS)Endothelin-Converting Enzyme (ECE)Acetohydroxyacid synthaseEndothelin-Converting EnzymeECEsystemic candidiasis antifungal drug efficacy biofilm ALS3 HWP1 ECE1SC5314Inhibitorinhibitorinhibit

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产品名称：
AB-22
目录号：
HY-178732
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