2. Anti-infection Metabolic Enzyme/Protease Apoptosis
  3. Bacterial MMP Apoptosis Fungal
  4. Methylisothiazolinone hydrochloride

Methylisothiazolinone hydrochloride  (Synonyms: 2-甲基-4-异噻唑啉-3-酮盐酸盐)

目录号: HY-W010243 纯度: 99.40%
COA 产品使用指南 技术支持

Methylisothiazolinone hydrochloride 是一种细菌真菌抑制剂和防腐剂，也是一种致敏剂。Methylisothiazolinone hydrochloride 可以激活人支气管上皮细胞中的基质金属蛋白酶 (MMPs) 来诱导细胞凋亡 (apoptosis) 和炎症反应。Methylisothiazolinone hydrochloride 可以通过 Th2/Th17 相关免疫反应失调来促进小鼠特应性皮炎的发展。Methylisothiazolinone hydrochloride 可引起大鼠脑血管内皮的线粒体损伤。

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Methylisothiazolinone hydrochloride

Methylisothiazolinone hydrochloride Chemical Structure

CAS No. : 26172-54-3

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥220
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100 mg ￥200
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250 mg ￥400
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500 mg ￥540
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1 g ￥720
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10 g   询价  

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Customer Review

Other Forms of Methylisothiazolinone hydrochloride:

Methylisothiazolinone hydrochloride 相关抗体

Top Publications Citing Use of Products

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methylisothiazolinone hydrochloride is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone hydrochloride can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone hydrochloride can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone hydrochloride can cause mitochondrial damage in the endothelium of rat cerebral blood vessels[1][2][3][4].
体外研究
(In Vitro)

Methylisothiazolinone (0-8 μg/mL, 24 h) hydrochloride 通过激活人支气管上皮细胞中的基质金属蛋白酶 (MMPs) 来诱导细胞凋亡和炎症反应[1]。
Methylisothiazolinone (0-2.5 μg/mL, 1 h) hydrochloride 可以引起脑内皮细胞中的线粒体损伤[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Methylisothiazolinone hydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: Bronchial epithelial cells (BEAS-2B cells)
Concentration: 0, 2, 4, 8 μg/mL
Incubation Time: 24 h
Result: Caused a decrease in cell viability to 81.0%, 67.9%, and 35.1% at doses of 2, 4, and 8 μg/mL, respectively.

Western Blot Analysis[1]

Cell Line: bEND.3 cell
Concentration: 0, 1, 2.5 μg/mL CMIT/MIT
Incubation Time: 1 h
Result: Increased the level of Drp-1 phosphorylated protein and decreased the level of Mfn-1 phosphorylated protein.
体内研究
(In Vivo)

Methylisothiazolinone (0.15 mg/kg; 1 次; 静脉注射) hydrochloride 可以提高大鼠脑血管内皮对内源性病理刺激的易感性并导致线粒体损伤[2]。
Methylisothiazolinone (20 或 40 μL; 处理皮肤 (20 μL), 第 1 天和第 8 天; 鼻内滴注 (40 μL), 第 15 天) hydrochloride 在哮喘小鼠中处理皮肤可引起致敏[3]。
Methylisothiazolinone (0.1875 mg/kg CMIT/MIT; 每天 1 次; 15 天; 表皮接触) hydrochloride 通过 Th2/Th17 相关免疫反应失调来促进小鼠特应性皮炎的发展[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SD rats (230-300 g and 7-8 weeks of age)[2]
Dosage: 0.15 mg/kg
Administration: Intravenous injection (i.v.); once
Result: Resulted in mitochondrial damage and a decrease in tight junction proteins.
Animal Model: Male C57Bl/6 and BALB/c mouse asthma models induced by chemistry (approximately 20 g, 6 weeks old)[3]
Dosage: 20 or 40 μL
Administration: Handled skin (20 μL), on days 1 and 8; intranasal instillation (40 μL), on day 15
Result: Induced an increase in T and B cell proliferation in ear lymph nodes, while producing IFN-γ.
Animal Model: Specific dermatitis (AD) female BALB/c mice established by sensitization of ovalbumin (OVA) epidermis (5 weeks old, n = 5 per group) weighing 16-20 g[4]
Dosage: 0.1875 mg/kg chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT)
Administration: Epidermal contact; once daily; 15 days
Result: Augmented the mRNA expression level of T helper (Th) 2-related cytokines (thymic stromal lymphopoietin, interleukin (IL)-6 and IL-13), Th2 chemokine (chemokine (C-C motif) ligand 17) and the population of CD4IL-4 cells in the skin.
分子量

151.61

Formula

C4H6ClNOS
CAS 号
性状

固体

颜色

White to off-white

中文名称

2-甲基-4-异噻唑啉-3-酮盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (659.59 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.5959 mL 32.9794 mL 65.9587 mL
5 mM 1.3192 mL 6.5959 mL 13.1917 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

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由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.40%

COA (293 KB) HNMR (115 KB) RP-HPLC (196 KB)

产品使用指南 (1538 KB)
参考文献

Methylisothiazolinone hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.5959 mL 32.9794 mL 65.9587 mL 164.8968 mL
5 mM 1.3192 mL 6.5959 mL 13.1917 mL 32.9794 mL
10 mM 0.6596 mL 3.2979 mL 6.5959 mL 16.4897 mL
15 mM 0.4397 mL 2.1986 mL 4.3972 mL 10.9931 mL
20 mM 0.3298 mL 1.6490 mL 3.2979 mL 8.2448 mL
25 mM 0.2638 mL 1.3192 mL 2.6383 mL 6.5959 mL
30 mM 0.2199 mL 1.0993 mL 2.1986 mL 5.4966 mL
40 mM 0.1649 mL 0.8245 mL 1.6490 mL 4.1224 mL
50 mM 0.1319 mL 0.6596 mL 1.3192 mL 3.2979 mL
60 mM 0.1099 mL 0.5497 mL 1.0993 mL 2.7483 mL
80 mM 0.0824 mL 0.4122 mL 0.8245 mL 2.0612 mL
100 mM 0.0660 mL 0.3298 mL 0.6596 mL 1.6490 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methylisothiazolinone26172-54-32-甲基-4-异噻唑啉-3-酮盐酸盐BacterialMMPApoptosisFungalMatrix metalloproteinasessterilizationallergymitochondrial damagedermatitisInhibitorinhibitorinhibit

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