1. Cell Cycle/DNA Damage Epigenetics Apoptosis
  2. HDAC Apoptosis
  3. MI-192

MI-192 是一种选择性 HDAC2HDAC3 抑制剂,IC50 分别为 30 nM 和 16 nM。MI-192 对 HDAC2/3 的选择性比其他 HDAC 异构体更高。MI-192 诱导髓系白血病细胞凋亡 (apoptosis)。抗癌和神经保护活性。

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MI-192 Chemical Structure

MI-192 Chemical Structure

CAS No. : 1415340-63-4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities[1][2].

体外研究
(In Vitro)

MI-192 (0.15-1 μM; 72 h) induces differentiation and is cytotoxic through promotion of apoptosis in acute myeloid leukaemic cell lines U937, HL60 and Kasumi-1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: HL60 and Kasumi-1 cells
Concentration: 150 nM, 300 nM, 500 nM, 1 μM
Incubation Time: 72 h
Result: Induced a substantial degree of apoptosis in both HL60 and Kasumi-1 cells.
体内研究
(In Vivo)

MI-192 (40 mg/kg; i.p; once a day; for 3 days) shows the neuroprotective activity in the mouse brain subjected to photothrombotic stroke[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male outbred mice CD-1 (20-25 g) with photothrombotic stroke (PTS)[2]
Dosage: 40 mg/kg
Administration: i.p; once a day; for 3 days
Result: Reduced the volume of the PTS-induced infarction core in the mouse brain, partly restored the functional symmetry in the forelimb use, decreased the level of PTS-induced apoptosis and acetylation of α-tubulin characteristic for stable microtubules, and increased the expression of GAP-43 in the cerebral cortex of the damaged hemisphere.
分子量

383.44

Formula

C24H21N3O2

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MI-192
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HY-110264
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