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  3. Millepachine

Millepachine 

目录号: HY-N7591 纯度: 99.65%
产品使用指南

Millepachine 是来自中草药 Millettia pachycarpa Benth 的生物活性天然查尔酮,在体内外对多种人类癌细胞均显示出强大的抗肿瘤作用。

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Millepachine Chemical Structure

Millepachine Chemical Structure

CAS No. : 1393922-01-4

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Description

Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo[1].

In Vitro

Millepachine (1.25-20 μM; 48 h) remarkably inhibits the proliferation of cisplatin-resistant A2780CP cells[1].
Millepachine (2-8 μM; 24 or 48 h) induces G2/M arrest and apoptosis cisplatin-sensitive A2780S and cisplatin-resistant A2780CP cells[1].
Millepachine (2-8 μM; 24 h) decreases topoisomerase II levels in A2780S and A2780CP cells[1].
Millepachine (2-8 μM; 24 h) inhibits ATP-binding cassette transporter activity in A2780CP cells[1].

Cell Proliferation Assay[1]

Cell Line: A2780CP cells
Concentration: 0, 1.25, 2.5, 5, 10, 20 μM
Incubation Time: 48 hours
Result: Inhibited the cells proliferation with an IC50 of 4 μM.

Cell Cycle Analysis[1]

Cell Line: A2780S and A2780CP cells
Concentration: 2, 4, 8 μM
Incubation Time: 24 or 48 hours
Result: Induced significant G2/M arrest both in both cells.
The percentage of cells in the G2/M fraction increased from 15.99% in vehicle cells to 24.93%, 60.67%, and 77.31% at dose of 2, 4, and 8 μM in A2780S cells, respectively.

Apoptosis Analysis[1]

Cell Line: A2780S and A2780CP cells
Concentration: 2, 4, 8 μM
Incubation Time: 24 or 48 hours
Result: The percentage of apoptotic cells increased from 1.49% in vehicle cells to 10.98%, 20.60%, and 39.43% at dose of 2, 4, and 8 μM in A2780S cells, respectively.
The percentage of apoptotic cells increased from 0.87% to 10.97%, 25.28%, and 37.59% in A2780CP cells, respectively.

Western Blot Analysis[1]

Cell Line: A2780S and A2780CP cells
Concentration: 0, 2, 4, 8 μM
Incubation Time: 24 hours
Result: Decreased the levels of topoisomerase II (TOPO II) in both cells.
In Vivo

Millepachine (20 mg/kg; i.v. every two days for 14 day) inhibits tumor growth in mice[1].
Millepachine (20 mg/kg; i.v. every two days for 14 day) does not induce acquired drug resistance in an excised A2780S xenograft model[1].

Animal Model: Female BALB/c nude mice (6 weeks) are injected A2780S or A2780CP cells[1]
Dosage: 20 mg/kg
Administration: I.v. every two days for 2-14 days
Result: Reduced tumor volume and tumor weight with the inhibitory rate of 73.21% and 65.58% in A2780S (after seven times injection) and A2780CP (after six times injection) xenograft model, respectively.
With low toxicity in vivo.
Molecular Weight

350.41

Formula

C₂₂H₂₂O₄

CAS No.

1393922-01-4

SMILES

O=C(C1=C2C(C=CC(C)(C)O2)=C(OC)C=C1)/C=C/C3=CC=C(OC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MillepachineApoptosisbioactivenaturalchalconeChineseherbalmedicineMillettiapachycarpaBenthantitumorcancerInhibitorinhibitorinhibit

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