(-)-Huperzine A-d₄ hydrochloride  (Synonyms: 石杉碱甲盐酸盐-d₄; Huperzine A-d₄)

(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease^{[1][2][3][4][5]}.

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。
(-)- Huperzine A (1 μM；2 小时) 减轻 Aβ23-35 (20 μM) 诱导的神经元损伤^[3]。
(-)- Huperzine A (100 μM) 在从大鼠海马体急性分离的 CA1 锥体神经元中的全细胞电压钳记录中可逆地抑制 NMDA 诱导的电流 (IC₅₀=126 μM)^[4]。br/>

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Huperzine A (0.1-0.2 mg/kg；腹腔注射；daily；for 12 days) 可减轻大鼠 icv 输注 β-淀粉样蛋白-(1-40) 引起的认知功能障碍和神经元变性^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

282.80

C₁₅H₁₅D₄ClN₂O

(-)-石杉碱甲盐酸盐-d₄；石杉碱甲盐酸盐-d₄

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. MA Xiao-Chao, XIN Jian, WANG Hai-Xue, et al. Acute effects of huperzine A and tacrine on rat liver. Acta Pharmacol ogica Sinica, 2003, 24(3):247-250.  [Content Brief]

  [3]. Rui Wang, et al. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin. 2006 Jan;27(1):1-26.  [Content Brief]

  [4]. J M Zhang, et al. Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.Neuroscience. 2001;105(3):663-9  [Content Brief]

  [5]. Maung Kyaw Moe Tun, et al. The pharmacology and therapeutic potential of (−)-huperzine A. J Exp Pharmacol. 2012; 4: 113–123.  [Content Brief]

  [6]. R Wang, et al. Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat. Eur J Pharmacol. 2001 Jun 15;421(3):149-56.  [Content Brief]