2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Mizolastine dihydrochloride

Mizolastine dihydrochloride  (Synonyms: 咪唑斯汀二盐酸盐)

目录号: HY-B0164A
产品使用指南

摩尔计算器

Mizolastine dihydrochloride 是一种口服有效的，具有高亲和力和特异性的外周组胺 H1 受体拮抗剂 (第二代抗组胺剂)。Mizolastine dihydrochloride 能有效抑制VEGF165、VEGF120、TNF-α 和 KC 的 mRNA 表达。Mizolastine dihydrochloride 可用于过敏性鼻炎和慢性特发性荨麻疹的研究。

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Mizolastine dihydrochloride Chemical Structure

Mizolastine dihydrochloride Chemical Structure

CAS No. : 1056596-82-7

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Mizolastine dihydrochloride 的其他形式现货产品:

Other Forms of Mizolastine dihydrochloride:

Mizolastine dihydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mizolastine dihydrochloride is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine dihydrochloride effectively inhibits mRNA expression of VEGF165, VEGF120, TNF-α and KC. Mizolastine dihydrochloride can be used in studies of allergic rhinitis and chronic idiopathic urticarial[1][2][3].

体外研究
(In Vitro)

Mizolastine dihydrochloride (1-10000 nM; 0.5-6 h) shows inhibitory effects on VEGF, KC and TNF-α release in mast cells[1].
Mizolastine dihydrochloride (0.1 µM; 4 h) significantly reduces VEGF165, VEGF120, TNF-α and KC mRNA expression in mast cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mizolastine dihydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: Mast cells (from Kunming mice)
Concentration: 1-10000 nM
Incubation Time: 0.5-6 h
Result: Markedly inhibited release of KC, VEGF and TNF-α in a time- and dose- dependent manner.

RT-PCR[1]

Cell Line: Mast cells (from Kunming mice)
Concentration: 0.1 µM
Incubation Time: 4 h
Result: Led to a significant reduction of induced VEGF165, VEGF120, TNF-α and KC mRNA synthesis.
体内研究
(In Vivo)

Mizolastine dihydrochloride (0.3 mg/kg; p.o.; single daily for 7 days) inhibits production of 5-LOX AA (arachidonic acid) metabolite leukotriene B4 (LTB4), and suppresses expression of 5-LOX, cytosolic PLA2 (cPLA2), 5-LOX-activating protein, and LTB4 receptor mRNA in the AA-induced inflammation model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (specific-pathogen-free; 234-254 g; 7 to 8-week-old; rat paw edema model)[2].
Dosage: 0.3 mg/kg
Administration: Oral gavage; single daily for 7 days.
Result: Significantly reduced paw edema by 21% at 1 h, and by 14‑18% between 2 and 4 h.
Inhibited inflammatory cell infiltration and significantly reduced levels of LTB4.
Suppressed expression of 5‑LOX, cPLA2, FLAP and LTB4r mRNA.
Clinical Trial
分子量

505.42

Formula

C24H27Cl2FN6O
CAS 号
中文名称

咪唑斯汀二盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mizolastine dihydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mizolastine1056596-82-7咪唑斯汀二盐酸盐Histamine Receptorsecond generation antihistamineallergic rhinitischronic idiopathic urticarialmast cellsInhibitorinhibitorinhibit

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