2. Epigenetics Apoptosis
  3. Histone Methyltransferase Apoptosis
  4. MM-401

MM-401 是一种 MLL1 H3K4 甲基转移酶抑制剂。MM-401 通过阻断 MLL1-WDR5 相互作用来抑制 MLL1 活性（IC50 值为 0.32 µM）。MM-401 可诱导细胞周期停滞、凋亡和分化。MM-401 可用于 MLL 白血病的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 MM-401 TFA 通常具有更好的水溶性和稳定性。

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MM-401 Chemical Structure

MM-401 Chemical Structure

CAS No. : 1442106-10-6

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MM-401 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 µM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia[1].

IC50 & Target

Ki: < 1 nM (WDR5); IC50: 0.9 nM (WDR5-MLL1 interaction), 0.32 µM (MLL1)[1].
体外研究
(In Vitro)

MM-401 maintains high binding affinity to WDR5 with a Ki value of < 1 nM and disrupts WDR5-MLL1 interaction with an IC50 value of 0.9 nM[1].
MM-401 is able to specifically inhibit MLL1 activity (IC50 value of 0.32µM) by blocking MLL1-WDR5 interaction and thus the complex assembly[1].
MM-401 (20 μM; 48 h) specifically inhibits MLL1-dependent H3K4 methylation in cells[1].
MM-401 induces similar changes in MLL-AF9 transcriptome as the MLL1 deletion[1].
MM-401 (10, 20, 40 μM; 48 h) specifically inhibits growth of MLL leukemia cells by inducing cell cycle arrest, apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MM-401 相关抗体:

Apoptosis Analysis[1]

Cell Line: Murine MLL-AF9 and Hoxa9/Meis1 cells
Concentration: 0, 20, 40 μM
Incubation Time: 48 h
Result: Specifically induced apoptosis of MLL-AF9 cells.

Cell Cycle Analysis[1]

Cell Line: Murine MLL-AF9 and Hoxa9/Meis1 cells
Concentration: 10, 20, 40 μM
Incubation Time: 48 h
Result: Induced prominent G1/S arrest in MLL-AF9 cells in a concentration dependent manner.

RT-PCR[1]

Cell Line: MLL-AF9 cells
Concentration: 20 μM
Incubation Time: 48 h
Result: Significantly decreased H3K4me, expression of 5 Hox A genes, especially Hoxa9 and Hoxa10.
分子量

586.73

Formula

C29H46N8O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MM-401 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM-4011442106-10-6MM401MM 401Histone MethyltransferaseApoptosisMLL1-WDR5 interactionMLL1histone methyltransferasesleukemiaH3K4cell cycleapoptosisdifferentiationInhibitorinhibitorinhibit

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