2. Autophagy
  3. Autophagy
  4. MOPIPP

MOPIPP 是一种新型吲哚基查尔酮、液泡素-1，是一种 MOMIPP (HY-119624) 的非致命液泡诱导 2-丙基类似物。MOPIPP 能诱导细胞液泡化，增加自噬体数目。MOPIPP 还会引发细胞巨泡式死亡 (methuosis)，并中断葡萄糖摄取和糖酵解代谢。MOPIPP 能够透过血脑屏障，对胶质母细胞瘤细胞有抑制作用。

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MOPIPP

MOPIPP Chemical Structure

CAS No. : 1485521-76-3

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规格 价格 是否有货 数量
5 mg ￥990
In-stock
10 mg ￥1584
In-stock
25 mg ￥3168
In-stock
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Customer Review

Other Forms of MOPIPP:

MOPIPP 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MOPIPP is a novel indolebased chalcone, and vacuolin-1, is a non-lethal vacuoleinducing 2-propyl analog of MOMIPP (HY-119624). MOPIPP induces cellular vacuolization and increases autophagosomes numbers. MOPIPP also triggers methuosis, and interrupts glucose uptake and glycolytic metabolism. MOPIPP can cross the blood-brain barrier and shows efficacy in suppressing tumor progression agaisnt glioblastoma cells[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
U-251 GI50
15.3 μM
Compound: 19
Growth inhibition of human U251 cells preincubated for 24 hrs followed by compound-washout measured at 48 hrs by sulforhodamine assay
Growth inhibition of human U251 cells preincubated for 24 hrs followed by compound-washout measured at 48 hrs by sulforhodamine assay
[PMID: 24527179]
体外研究
(In Vitro)

MOPIPP (10 μM; 48 h) induces cellular vacuolization but does not cause cell death in U251 glioblastoma cells, exhibiting characteristics of late endosomes[1][2].
MOPIPP (10 μM; 24 h) results an increasing LC3 fluorescence associated with the number of autophagosomes and inhibits fusion of autophagosomes with lysosomes[1].
MOPIPP (10 μM; 24 h) increases the amounts of exosomal marker proteins in vesicle fractions recovered from 293T cells[2].
MOMIPP (10 μM; 24 h and 5 h, respectively) causes early disruptions of glucose uptake and glycolytic metabolism, induces methuosis, a form of non-apoptotic cell death, in glioblastoma and other cancer cell lines[3].
MOMIPP (10 μM; 4 h and 24 h) selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MOPIPP 相关抗体:

Immunofluorescence[1]

Cell Line: U251 glioblastoma cells
Concentration: 10 μM
Incubation Time: 24 hours; incubated with 2.5 μg/ml Acridine Orange (HY-101879) for 45 min
Result: Caused accumulation of autophagosome markers.
Increased punctate LC3 fluorescence and suggested an increase in the number of autophagosomes in cells.

Western Blot Analysis[3]

Cell Line: U251 glioblastoma cells
Concentration: 10 μM
Incubation Time: 4 and 24 hours
Result: Triggered increaseing phosphorylation of Bcl-2 and Bcl-xL, accompanied the activation of JNK.
体内研究
(In Vivo)

MOMIPP (80 mg/kg; i.p.; single dose) readily penetrates the bloodbrain barrier in female Swiss Webster Mice and (80 mg/kg; i.p.; every 24 h; 15 d) is effective in suppressing progression of intracerebral glioblastoma xenografts in female NCR-Foxn1 mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Intracerebral xenograft model in NCR-Foxn1 mice (female, 7-8 weeks, injected with U251- LUC cells)[3]
Dosage: 80 mg/kg
Administration: Intraperitoneal injection; every 24 hours for 15 days; monitored tumor progression by BLI on the days 7, 11, 15
Result: Significantly inhibited tumor progression.
分子量

320.39

Formula

C20H20N2O2
CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 8.33 mg/mL (26.00 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1212 mL 15.6060 mL 31.2120 mL
5 mM 0.6242 mL 3.1212 mL 6.2424 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

MOPIPP 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1212 mL 15.6060 mL 31.2120 mL 78.0299 mL
5 mM 0.6242 mL 3.1212 mL 6.2424 mL 15.6060 mL
10 mM 0.3121 mL 1.5606 mL 3.1212 mL 7.8030 mL
15 mM 0.2081 mL 1.0404 mL 2.0808 mL 5.2020 mL
20 mM 0.1561 mL 0.7803 mL 1.5606 mL 3.9015 mL
25 mM 0.1248 mL 0.6242 mL 1.2485 mL 3.1212 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MOPIPP1485521-76-3Autophagyexosomevacuolesendosomeglioblastomachalconesvacuolincell deathmacropinocytosislysosomesmethuosisInhibitorinhibitorinhibit

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产品名称：
MOPIPP
目录号：
HY-148114
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