2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. MuRF1-IN-1

MuRF1-IN-1 是一种口服有效的 MuRF1 抑制剂。MuRF1-IN-1 可抑制 MuRF1 与肌联蛋白相互作用及 E3 连接酶活性。MuRF1-IN-1 能够减轻心脏恶病质中的骨骼肌萎缩和功能障碍。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

MuRF1-IN-1

MuRF1-IN-1 Chemical Structure

CAS No. : 445222-91-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥463
In-stock
5 mg ￥1088
In-stock
10 mg ￥1738
In-stock
25 mg ￥2988
In-stock
50 mg ￥4250
In-stock
100 mg ￥5938
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

MuRF1-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MuRF1-IN-1 is an orally active MuRF1 inhibitor. MuRF1-IN-1 can inhibit the interaction between MuRF1 and titin as well as E3 ligase activity. MuRF1-IN-1 can alleviate skeletal muscle atrophy and dysfunction in cardiac cachexia[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
U-87MG ATCC IC50
78 μg/mL
Compound: 6a
Cytotoxicity against Homo sapiens (human) U87 cells by MTT assay
Cytotoxicity against Homo sapiens (human) U87 cells by MTT assay
10.1007/s00044-012-0249-x
体外研究
(In Vitro)

MuRF1-IN-1 (Compound 704946) (0.1-10 µM; 26 h) 在 C2C12 肌管中抑制了 Dexamethasone (HY-14648) 诱导的 MuRF1 mRNA 上调，并完全阻止了肌纤维萎缩[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MuRF1-IN-1 相关抗体:

Real Time qPCR[1]

Cell Line: Dexamethasone (HY-14648) treate C2C12 cells
Concentration: 0.1 and 10 µM
Incubation Time: Pretreated with 2 h, then co-incubation for 24 h
Result: Reduced MuRF1 mRNA levels at 10 μM, but not 0.1 μM.
体内研究
(In Vivo)

MuRF1-IN-1 (0.1% w/w; 饲料管理; 7 周) 在小鼠心脏恶病质模型中具有改善作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice aged 8 weeks old treated monocrotaline (HY-N0750) to induce cardiac cachexia[1]
Dosage: 0.1% w/w
Administration: Dietary administration; 7 weeks
Result: Prevented atrophy in tibialis anterior (TA) muscle, with preserved wet weight and fibre cross-sectional area (CSA) compared to monocrotaline-treated controls. Wet weights of extensor digitorum longus (EDL) and soleus muscles were normalized to sham levels.
Restored diaphragm muscle shortening velocity and power to sham levels, reversing the ~20% impairment induced by cardiac cachexia.
Downregulated MuRF1 protein expression, normalized pro-apoptotic protein BAX and translation initiation factor eIF2B-δ, and attenuated actin ubiquitination and proteasome activity.
分子量

321.33

Formula

C18H15N3O3
CAS 号
性状

固体

颜色

Off-white to gray

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (389.01 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1121 mL 15.5603 mL 31.1207 mL
5 mM 0.6224 mL 3.1121 mL 6.2241 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

MuRF1-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1121 mL 15.5603 mL 31.1207 mL 77.8016 mL
5 mM 0.6224 mL 3.1121 mL 6.2241 mL 15.5603 mL
10 mM 0.3112 mL 1.5560 mL 3.1121 mL 7.7802 mL
15 mM 0.2075 mL 1.0374 mL 2.0747 mL 5.1868 mL
20 mM 0.1556 mL 0.7780 mL 1.5560 mL 3.8901 mL
25 mM 0.1245 mL 0.6224 mL 1.2448 mL 3.1121 mL
30 mM 0.1037 mL 0.5187 mL 1.0374 mL 2.5934 mL
40 mM 0.0778 mL 0.3890 mL 0.7780 mL 1.9450 mL
50 mM 0.0622 mL 0.3112 mL 0.6224 mL 1.5560 mL
60 mM 0.0519 mL 0.2593 mL 0.5187 mL 1.2967 mL
80 mM 0.0389 mL 0.1945 mL 0.3890 mL 0.9725 mL
100 mM 0.0311 mL 0.1556 mL 0.3112 mL 0.7780 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MuRF1-IN-1445222-91-3E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseC2C12 cellscardiac cachexia modelInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
MuRF1-IN-1
目录号：
HY-129531
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z