2. Cell Cycle/DNA Damage Apoptosis
  3. ClpP Apoptosis
  4. NCA029

NCA029 是一种有效的智人酪蛋白分解蛋白酶 P (HsClpP) 激活剂，EC50 为 0.15 μM。NCA029 靶向 HsClpPP，激活 ATF3 依赖性整合应激反应，导致结肠癌细胞死亡。

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NCA029 Chemical Structure

NCA029 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

NCA029 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with an EC50 of 0.15 μM. NCA029 acts on HsClpP to activate an ATF3-dependent integrative stress response, leading to colon cancer cell death[1].

体外研究
(In Vitro)

NCA029 抑制人结肠腺癌细胞系 (COAD)，对 HCT116、SW620、HCT15、SW480 和 DLD-1 的 IC50 值分别为 1.1 μM、1.5 μM、3.5 μM、5.4 μM 和 3.1 μM[1] 。
NCA029 会导致 HCT116 细胞内 ROS 水平升高，且呈剂量依赖性，表明呼吸链活性受损[1]。
NCA029（0.5-2 μM；48 小时）抑制肿瘤细胞增殖和转移[1]。
NCA029（0.5-2 μM；48 小时）剂量依赖性地诱导 HCT116 细胞凋亡并将细胞阻滞于 G2/M 期[1]。
NCA029 (0.5-2 μM) 剂量依赖性地降低 SDHB 的表达，上调促凋亡蛋白 BAX 的表达，同时下调抗凋亡蛋白 Bcl-2 的表达[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NCA029 相关抗体:

Cell Migration Assay [1]

Cell Line: HCT116 cells
Concentration: 0.5 μM, 1 μM, 2 μM
Incubation Time: 48 h
Result: Resulted in a dose-dependent reduction in HCT116 clone formation ability.

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 0.5 μM, 1 μM, 2 μM
Incubation Time: 48 h
Result: Significantly increased the number of cells in the G2 phase.
体内研究
(In Vivo)

NCA029（1.25-5 mg/kg；静脉注射；每周两次；持续 21 天）显着抑制 HCT116 异种移植物中的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice bearing HCT116 tumors[1]
Dosage: 1.25, 2.5, and 5 mg/kg
Administration: intravenous administration; twice weekly; for 21 days
Result: Inhibited tumor growth in mice xenograft model.
分子量

399.41

Formula

C22H20F3N3O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NCA029 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCA029NCA 029NCA-029ClpPApoptosisCaseinolytic protease PHsClpP activatorcolon cancermitochondrial dysfunctionATF3Inhibitorinhibitorinhibit

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产品名称：
NCA029
目录号：
HY-163319
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