1. Others GPCR/G Protein Neuronal Signaling
  2. Isotope-Labeled Compounds 5-HT Receptor Adrenergic Receptor
  3. Nefazodone-d6 dihydrochloride

Nefazodone-d6 dihydrochloride  (Synonyms: BMY-13754-d6 dihydrochloride; MJ-13754-1-d6 dihydrochloride)

目录号: HY-B1396S1
产品使用指南

Nefazodone-d6 (dihydrochloride) 是 Nefazodone (hydrochloride) 氘代物。Nefazodone hydrochloride (BMY-13754) 是一种强效和选择性的 5HT2A (Ki=5.8 nM) 拮抗剂,对 5-HT 和去甲肾上腺素摄取具有中度抑制作用 (IC50 分别为 290 和 300 nM)。Nefazodone hydrochloride 是一种苯哌嗪类抗抑郁药,具有微弱的 α-肾上腺素阻断活性。

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Nefazodone-d<sub>6</sub> dihydrochloride Chemical Structure

Nefazodone-d6 dihydrochloride Chemical Structure

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规格 是否有货
1 mg
询价
5 mg
询价

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Customer Review

Other Forms of Nefazodone-d6 dihydrochloride:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nefazodone-d6 (dihydrochloride) is deuterium labeled Nefazodone (hydrochloride). Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

548.97

Formula

C25H28D6Cl3N5O2

中文名称

萘法唑酮二盐酸盐-d6;二盐酸萘法唑酮-d6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Nefazodone-d6 dihydrochloride
目录号:
HY-B1396S1
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