2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. nSMase2-IN-1

nSMase2-IN-1 是一种口服有效的中性鞘磷脂酶2 (nSMase2) 抑制剂，其 IC50 值为0.13 ± 0.06 μM。nSMase2-IN-1 在肝脏微粒体中代谢稳定，口服后脑血浆比值较高。nSMase2-IN-1 可用于神经系统相关疾病的研究。

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nSMase2-IN-1 Chemical Structure

nSMase2-IN-1 Chemical Structure

CAS No. : 2968322-24-7

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nSMase2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Phospholipase 亚型特异性产品:

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Phospholipase A PLD

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

nSMase2-IN-1 is an orally active Neutral sphingomyelinase 2 (nSMase2) inhibitor with an IC50 value of 0.13 ± 0.06 μM. nSMase2-IN-1 is metabolically stable in liver microsomes and orally available with a favorable brain-to-plasma ratio. nSMase2-IN-1 can be used for nervous system disease research[1].

体外研究
(In Vitro)

nSMase2-IN-1 (Compound 11j) (5μM, 60 分钟) 在大鼠肝微粒体中表现出良好的代谢稳定性，1 小时后残留 95%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

nSMase2-IN-1 相关抗体:
体内研究
(In Vivo)

nSMase2-IN-1 (Compound 11j) (10 mg/kg, 口服灌胃, 30 min 和 2 h 后取样检测) 口服有效，在雄性Wistar 大鼠中具有脑渗透作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (Pharmacokinetic assay)[1]
Dosage: 10 mg/kg
Administration: Oral gavage (p.o.)
Result: Absorbed quickly resulting in plasma concentration of more than 2 μM and had higher brain levels than plasma at 0.5 h.
分子量

247.30

Formula

C12H17N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

nSMase2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

nSMase2-IN-12968322-24-7Phospholipasephosphodiesteraseneutral sphingomyelinase 2sphingomyelinceramideInhibitorinhibitorinhibit

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