2. Immunology/Inflammation
  3. CD3
  4. Obrindatamab

Obrindatamab  (Synonyms: MGD009)

目录号: HY-P99762 纯度: 99.58%
COA

摩尔计算器

Obrindatamab 是一种人源化抗 B7-H3/CD3 双特异性抗体。Obrindatamab 结合 B7-H3 和 CD3，从而介导针对表达 B7-H3 的癌细胞的重定向细胞毒性 T 淋巴细胞 (CTL) 活性。Obrindatamab 可用于癌症研究。

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Obrindatamab Chemical Structure

Obrindatamab Chemical Structure

CAS No. : 2069959-72-2

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规格 价格 是否有货 数量
1 mg ￥6500
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Obrindatamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Obrindatamab is a humanized anti-B7-H3/CD3 bispecific antibody. Obrindatamab binds to B7-H3 and CD3, thereby mediating redirected cytotoxic T-lymphocyte (CTL) activity against B7-H3-expressing cancer cells. Obrindatamab can be used in research of cancer[1].

体外研究
(In Vitro)

MGD009 (MGD009) 结合人和食蟹猴 CD3 和 B7-H3，对人 CD3ε/δ、食蟹猴 CD3ε/δ、人 B7-H3-His 和食蟹猴 B7-H3-His 的 KD 值分别为 13.9、14.7、24.6 和 30.2 nM[1]。
Obrindatamab (0.01-1000 ng/mL; A498, U87, 22Rv1, 和 Detroit562 细胞) 介导多种 B7-H3 表达肿瘤细胞系的重定向杀伤[1]。
Obrindatamab (0.01-1000 ng/mL；PBMC 和 A498 细胞) 介导的 T 细胞活化和增殖具有靶抗原依赖性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Obrindatamab 相关抗体:
体内研究
(In Vivo)

Obrindatamab (MGD009; 0.004-1 mg/kg; i.v.) 抑制人 T 细胞或 PBMC 重建小鼠中表达 B7-H3 的肿瘤异种移植物的生长和肿瘤消退[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID mice with Co-mix mouse xenograft model, Established tumor model in human T-cell reconstituted NSG b2m-/- mice, Established tumor model in human T-cell reconstituted MHC1-/- mice[1]
Dosage: 0.004-1 mg/kg
Administration: intravenous injection
Result: Had antitumor activity in multiple in vivo models.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Obrindatamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Obrindatamab2069959-72-2MGD009MGD 009MGD-009CD3Cluster of differentiation 3cytotoxic T-lymphocytecancerA498U8722Rv1Detroit562Inhibitorinhibitorinhibit

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