2. 诱导疾病模型产品 Metabolic Enzyme/Protease
  3. 神经系统疾病模型 Phosphatase
  4. 阿尔兹海默症模型
  5. Okadaic acid ammonium salt

Okadaic acid ammonium salt  (Synonyms: 冈田酸铵盐)

目录号: HY-115760
产品使用指南

摩尔计算器

Okadaic acid ammonium salt 是一种海洋毒素，是蛋白质磷酸酶 (PP) 的抑制剂，包括 PP1 (IC50=15-50 nM)、PP2A (IC50=0.1-0.3 nM)、PP3 (IC50=3.7-4 nM)、PP4 (IC50=0.1 nM) 和 PP5 (IC50=3.5 nM)，其中对 PP2A 的亲和力最显著，但不抑制 PP2C。Okadaic acid ammonium salt 通过抑制 PP 增加了多种蛋白的磷酸化，并具有肿瘤启动子的作用。Okadaic acid ammonium salt 诱导 tau 蛋白磷酸化。

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Okadaic acid ammonium salt Chemical Structure

Okadaic acid ammonium salt Chemical Structure

CAS No. : 175522-42-6

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Okadaic acid ammonium salt 的其他形式现货产品:

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Other Forms of Okadaic acid ammonium salt:

Okadaic acid ammonium salt 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Okadaic acid ammonium salt, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid ammonium salt has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid ammonium salt increases of phosphorylation of a number of proteins by inhibiting PP, and acts as a tumor promoter. Okadaic acid ammonium salt induces tau phosphorylation[1][2].

IC50 & Target[1]

PP1

15-50 nM (IC50)

PP2A

0.1-0.3 nM (IC50)

PP3

3.7-4 nM (IC50)

PP4

0.1 nM (IC50)

PP5

3.5 nM (IC50)

PP2B

~4000 nM (IC50)

PP7

＞1000 nM (IC50)

体外研究
(In Vitro)

Okadaic acid ammonium salt (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3].
Okadaic acid (10 nM, 8 hours) ammonium salt increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Okadaic acid ammonium salt 相关抗体:

Cell Proliferation Assay[3]

Cell Line: AGS, MNK-45 and Caco 2 cell lines
Concentration: 0-100 nM
Incubation Time: 24 h or 48 h
Result: Inhibited the proliferation of AGS, MNK-45, Caco 2 cells.
体内研究
(In Vivo)

Okadaic acid ammonium salt (100 μM; injected unilaterally to the lateral amygdala) induces Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female wild-type C57BL/6 mice (6 to 8 months)[5]
Dosage: 100 μM
Administration: Injected unilaterally to the lateral amygdala
Result: Induced Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection.
分子量

822.03

Formula

C44H71NO13
CAS 号
中文名称

冈田酸铵盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Okadaic acid ammonium salt 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Okadaic acid175522-42-6冈田酸铵盐Phosphatasemarine toxinAGSMNK-45Caco 2 cellsphosphorylationtumor promoterDrp1Inhibitorinhibitorinhibit

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