2. 诱导疾病模型产品 Metabolic Enzyme/Protease Apoptosis
  3. 神经系统疾病模型 Phosphatase Apoptosis
  4. 阿尔兹海默症模型
  5. Okadaic acid sodium

Okadaic acid sodium  (Synonyms: 冈田酸钠盐, 软海绵酸钠盐)

目录号: HY-N6785A
产品使用指南

摩尔计算器

Okadaic acid sodium 是一种海洋毒素，是蛋白质磷酸酶 (PP) 的抑制剂，包括 PP1 (IC50=15-50 nM)、PP2A (IC50=0.1-0.3 nM)、PP3 (IC50=3.7-4 nM)、PP4 (IC50=0.1 nM) 和 PP5 (IC50=3.5 nM)，其中对 PP2A 的亲和力最显著，但不抑制 PP2C。Okadaic acid sodium 通过抑制 PP 增加了多种蛋白的磷酸化，并具有肿瘤启动子的作用。Okadaic acid sodium 诱导 tau 蛋白磷酸化。

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Okadaic acid sodium Chemical Structure

Okadaic acid sodium Chemical Structure

CAS No. : 209266-80-8

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Okadaic acid sodium 的其他形式现货产品:

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Other Forms of Okadaic acid sodium:

Okadaic acid sodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation[1][2].

IC50 & Target[1]

PP1

15-50 nM (IC50)

PP2A

0.1-0.3 nM (IC50)

PP3

3.7-4 nM (IC50)

PP4

0.1 nM (IC50)

PP5

3.5 nM (IC50)

PP2B

~4000 nM (IC50)

PP7

>1000 nM (IC50)

体外研究
(In Vitro)

Okadaic acid sodium (0-100 nM；24 小时或 48 小时) 抑制 AGS、MNK-45、Caco 2 细胞的增殖[3]。
Okadaic acid sodium (10 nM；8 小时) 增加大鼠皮层神经元中的 Drp1 磷酸化和线粒体裂变[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Okadaic acid sodium 相关抗体:

Cell Proliferation Assay[3]

Cell Line: AGS, MNK-45 and Caco 2 cell lines
Concentration: 0-100 nM
Incubation Time: 24 h or 48 h
Result: Inhibited the proliferation of AGS, MNK-45, Caco 2 cells.
体内研究
(In Vivo)

Okadaic acid sodium (100 μM；单侧注射到外侧杏仁核) 在注射后 24 小时，诱导解剖学上不同大脑区域的 Tau 磷酸化和蛋白质聚集[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

826.98

Formula

C44H67NaO13
CAS 号
性状

油状物

颜色

Colorless to light yellow

中文名称

冈田酸钠盐, 软海绵酸钠盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Okadaic acid sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Okadaic acid209266-80-8冈田酸钠盐, 软海绵酸钠盐PhosphataseApoptosisHalichondriaserine/threonine-specificprotein phosphatasesmarine toxincancerbrainInhibitorinhibitorinhibit

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