2. Anti-infection
  3. Bacterial
  4. PA2-GNU7

PA2-GNU7 是一种抗菌肽 (AMP)。PA2-GNU7 表现出强效的抗菌活性，对铜绿假单胞菌、大肠杆菌、沙门氏菌、金黄色葡萄球菌和白色念珠菌的最小抑菌浓度 (MIC) 分别为 2 μM、1 μM、2 μM、2 μM 和 8 μM。PA2-GNU7 能快速且选择性地杀灭铜绿假单胞菌，而不影响其他共生菌。PA2-GNU7 显著提高感染铜绿假单胞菌的小鼠存活率。PA2-GNU7 可用于研究和开发针对多重耐药性铜绿假单胞菌感染的治疗剂。

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Custom Peptide Synthesis

PA2-GNU7

PA2-GNU7 Chemical Structure

CAS No. : 2387505-19-1

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PA2-GNU7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PA2-GNU7 is an antimicrobial peptide (AMP). PA2-GNU7 exhibits potent antimicrobial activity with minimal inhibitory concentration (MIC) against P. aeruginosa, E. coli, S. typhimurium, S. aureus, and C. albicans are 2 μM, 1 μM, 2 μM, 2 μM, and 8 μM, respectively. PA2-GNU7 rapidly and selectively kills Pseudomonas aeruginosa without affecting other commensal bacteria. PA2-GNU7 significantly improves survival of mice infected with P. aeruginosa. PA2-GNU7 can be used for the research and development of therapeutic agents against MDR Pseudomonas aeruginosa infections[1].

体外研究
(In Vitro)

PA2-GNU7 (21 h) 表现出强效的抗菌活性，对铜绿假单胞菌、大肠杆菌、沙门氏菌、金黄色葡萄球菌和白色念珠菌的最小抑菌浓度 (MIC) 分别为 2 μM、1 μM、2 μM、2 μM 和 8 μM[1]。
PA2-GNU7 (1 μM) 在双菌种培养 (1:1 铜绿假单胞菌与大肠杆菌或沙门氏菌) 中选择性地杀灭铜绿假单胞菌[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PA2-GNU7 相关抗体:
体内研究
(In Vivo)

PA2-GNU7 (15-25 mg/kg，腹腔注射，感染后 30 分钟给药) 显著提高感染铜绿假单胞菌的 BALB/c 小鼠的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (6-8 weeks old, female) infected with 2×107 CFU MDR P. aeruginosa[1]
Dosage: 15 mg/kg or 25 mg/kg
Administration: Intraperitoneal injection 30 min post-infection
Result: Achieved significantly improved survival rates.
Reduced bacterial loads in the liver, kidney, and spleen.
分子量

3372.11

Formula

C150H276N50O37
CAS 号
Sequence

Ser-Gln-Arg-Lys-Leu-Ala-Ala-Lys-Leu-Thr-Ser-Lys-Gly-Gly-Gly-Arg-Leu-Leu-Arg-Pro-Leu-Leu-Gln-Leu-Leu-Lys-Gln-Lys-Leu-Arg
Sequence Shortening

SQRKLAAKLTSKGGGRLLRPLLQLLKQKLR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PA2-GNU7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PA2-GNU72387505-19-1BacterialAntimicrobial peptideHybrid peptideMultidrug-resistant Pseudomonas aeruginosaOprFSelective antimicrobial activityInhibitorinhibitorinhibit

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目录号：
HY-P11091
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