1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. PD-1/PD-L1-IN 3

PD-1/PD-L1-IN 3,一种大环肽,是一种有效和选择性的 PD-1/PD-L1CD80/PD-L1 的相互作用抑制剂。PD-1/PD-L1-IN 3 通过与 PD-L1 结合来干扰 PD-L1PD-1 和 CD80 的结合,IC50 值分别为 5.60 nM 和 7.04 nM。PD-1/PD-L1-IN 3 可用于各种疾病的研究,包括癌症和传染病。详细信息请参考专利文献 WO2014151634A1 中的化合物 No.1。

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PD-1/PD-L1-IN 3 Chemical Structure

PD-1/PD-L1-IN 3 Chemical Structure

CAS No. : 1629654-95-0

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PD-1/PD-L1-IN 3 的其他形式现货产品:

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Other Forms of PD-1/PD-L1-IN 3:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD-1/PD-L1-IN 3, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 can be used for the research of various diseases, including cancer and infectious diseases[1].

IC50 & Target

IC50: 5.60 nM (PD-1/PD-L1); 7.04 nM (CD80/PD-L1)[1]

体外研究
(In Vitro)

PD-1/PD-L1-IN 3 (0.1 nM-10 μM) inhibits the binding of PD-1 and CD80 to PD-L1, with IC50s of 5.60 nM and 7.04 nM[1].
PD-1/PD-L1-IN 3 blocks the binding of recombinant PD-L1-Ig to Jurkat-PD-1 cells, and also block binding of recombinant PD-1-Ig to either L2987 or LK35.2-hPD-L1, with IC50s of 26 nM, 12 nM, and 3.5 nM, respectively[1].
PD-1/PD-L1-IN 3 (0.001-100 μM) promotes IFN secretion by CMV-specific T cells in a dose-dependent manner, with an EC50 of 400 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1852.17

Formula

C89H126N24O18S

CAS 号
Sequence Shortening

Maa-FANPHL-Sar-WSW-Nle-Nle-RCG (Disulfide bridge: Maa1-Cys15)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
PD-1/PD-L1-IN 3
目录号:
HY-103048
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