1. Neuronal Signaling
  2. Sigma Receptor
  3. PD 144418 oxalate

PD 144418 oxalate 

目录号: HY-108512A
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PD 144418 oxalate 是一种高亲和力,强效和选择性的 sigma 1 受体 (σ1 receptor) 配体 (对 σ1 和 σ2 的 Ki 值分别为 0.08 nM 和 1377 nM),对其他受体,离子通道和酶没有任何显着的亲和力。PD 144418 oxalate 具有潜在的抗精神病活性。

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PD 144418 oxalate Chemical Structure

PD 144418 oxalate Chemical Structure

CAS No. : 1794760-28-3

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PD 144418 oxalate is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 oxalate devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 oxalate shows potential antipsychotic activity[1][2].

IC50 & Target

Ki: 0.08 nM (σ1 receptor) and 1377 nM (σ2 receptor)[1]

(In Vitro)

In vitro, PD 144418 reverses the N-methyl-D-aspartate (NMDA)-induced increase in cyclic GMP (cGMP) in rat cerebellar slices without affecting the basal levels, suggesting that σ1 sites may be important in the regulation of glutamine-induced actions. PD 144418 potentiates the decrease in 5-hydroxytryptophan caused by Haloperidol in the mesolimbic region, but by itself has no effect in 5-HT and dopamine (DA) synthesis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(In Vivo)

PD 144418 (10 mg/kg; intraperitoneal injection; male CD-1 mice) treatment antagonizes Mescaline-induced scratching at doses that did not alter spontaneous motor activity, with PD 144418 showing ED50 values of 7.0 mg/kg i.p.[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice induced with Mescaline[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; once
Result: Antagonized mescaline-induced scratching at doses that did not alter spontaneous motor activity.







Room temperature in continental US; may vary elsewhere.


4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥98.0%


PD 144418 oxalate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.


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PD 144418 oxalate