1. Apoptosis Metabolic Enzyme/Protease
  2. Apoptosis Necroptosis Endogenous Metabolite
  3. Pectic acid

Pectic acid  (Synonyms: Methyl protopectin; Polygalacturonic acid)

目录号: HY-N10520
产品使用指南

Pectic acid (Methyl protopectin) 是一种聚半乳糖醛酸,可诱导垂体肿瘤细胞凋亡 (apoptosis) 和坏死 (necrosis)。Pectic acid 可用于癌症和自身免疫性疾病的研究。

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Pectic acid Chemical Structure

Pectic acid Chemical Structure

CAS No. : 9046-40-6

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规格 价格 是否有货 数量
50 mg ¥2200
1 - 2 周
100 mg ¥3520
1 - 2 周
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500 mg   询价  

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell apoptosis and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease[2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Pectic acid (2.5-100 μg/mL, 30 min) stimulates the release of prolactin (PRL) in GH3/B6 cells, without affecting the viability of cells[1].
Pectic acid (100 μg/mL-5 mg/mL, 6-48 h) increases cell death and DNA damage in GH3/B6 cells, detected by MTT assay and AO/EB staining[2].
Pectic acid (100 μg/mL-1 mg/mL, 24 h) induces apoptosis in GH3/B6 cells in a dose-dependent manner[2].
Pectic acid (2.5-5 mg/mL, 24 h) induces necrosis in GH3/B6 cells, confirmed by PI staining[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[2]

Cell Line: GH3/B6 cells
Concentration: 1 mg/mL
Incubation Time: 24 h
Result: Induced sub G1 events, and DNA fragmentation, which was correlated with the number of the apoptotic cells.
体内研究
(In Vivo)

Pectic acid (25 and 100 mg/kg, oral gavage) increases colon length, downregulates disease activity index, histopathological score and proinflammatory cytokine levels in Ulcerative colitis (UC) mice[3].
Pectic acid (6.25 and 12.5 mg/kg, intravenous injection) rescues the reduction in colon length in UC mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ulcerative colitis (UC) mice[3]
Dosage: 25, 100 mg/kg
Administration: Oral gavage
Result: Exhibited the longest colon, lowest DAI, and minimum histopathological score.
Decreased the proinflammatory cytokines in the colonic tissue of UC mice.
Animal Model: Ulcerative colitis (UC) mice[3]
Dosage: 6.25, 12.5 mg/kg
Administration: Intravenous injection
Result: Decreased the spleen and thymus index.
Restored the Th17/Treg balance in the spleen and lamina propria of UC mice.
Improved the gut microbiota composition.
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pectic acid
目录号:
HY-N10520
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