Pectic acid  (Synonyms: Methyl protopectin; Polygalacturonic acid)

Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell apoptosis and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease^[2][3].

Pectic acid (2.5-100 μg/mL, 30 min) stimulates the release of prolactin (PRL) in GH3/B6 cells, without affecting the viability of cells^[1].
Pectic acid (100 μg/mL-5 mg/mL, 6-48 h) increases cell death and DNA damage in GH3/B6 cells, detected by MTT assay and AO/EB staining^[2].
Pectic acid (100 μg/mL-1 mg/mL, 24 h) induces apoptosis in GH3/B6 cells in a dose-dependent manner^[2].
Pectic acid (2.5-5 mg/mL, 24 h) induces necrosis in GH3/B6 cells, confirmed by PI staining^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pectic acid (25 and 100 mg/kg, oral gavage) increases colon length, downregulates disease activity index, histopathological score and proinflammatory cytokine levels in Ulcerative colitis (UC) mice^[3].
Pectic acid (6.25 and 12.5 mg/kg, intravenous injection) rescues the reduction in colon length in UC mice^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

9046-40-6

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Delaram Eslimi, et al. Pectic acid effects on prolactin secretion in GH3/B6 rat pituitary cell line. Iran Biomed J. 2008 Jul;12(3):167-72.  [Content Brief]

  [2]. Farnoosh Attari, et al. Apoptotic and necrotic effects of pectic acid on rat pituitary GH3/B6 tumor cells. Iran Biomed J. 2009 Oct;13(4):229-36.  [Content Brief]

  [3]. Jie Song, et al. Effects of oral administration and intravenous injection of polygalacturonic acid on the immunomodulation and gut microbiota in UC mice. Int J Biol Macromol. 2022 Sep 30;217:150-160.  [Content Brief]