2. Others Stem Cell/Wnt Immunology/Inflammation Metabolic Enzyme/Protease TGF-beta/Smad PI3K/Akt/mTOR MAPK/ERK Pathway Autophagy
  3. Biochemical Assay Reagents β-catenin Wnt Arginase TGF-beta/Smad mTOR Akt ERK Atg8/LC3 p62 Autophagy
  4. Perfluoroundecanoic acid

Perfluoroundecanoic acid  (Synonyms: 全氟十一烷酸； 二十一氟十一烷酸)

目录号: HY-W142432 纯度: 99.85%
COA 产品使用指南 技术支持

Perfluoroundecanoic acid 是一种全氟烷基物质 (PFAS)。Perfluoroundecanoic acid 是一种口服有效的氧化应激诱导剂。Perfluoroundecanoic acid 促进巨噬细胞 M2 极化，激活 Wnt/β-catenin 信号通路，并增强 β-catenin 的核积累。Perfluoroundecanoic acid 诱导的 M2 表型巨噬细胞在体外和体内加速肿瘤进展。Perfluoroundecanoic acid 通过氧化应激诱导雄性 Swiss 小鼠的 DNA 损伤、生殖和病理生理功能障碍。Perfluoroundecanoic acid 通过诱导氧化应激和自噬 (Autophagy) 抑制青春期雄性大鼠的 Leydig 细胞发育。Perfluoroundecanoic acid 加速 1 型糖尿病小鼠模型中胰岛炎的发展。 Perfluoroundecanoic acid 可用于卵巢癌、1 型糖尿病和炎症研究。

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Perfluoroundecanoic acid

Perfluoroundecanoic acid Chemical Structure

CAS No. : 2058-94-8

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规格 价格 是否有货 数量
500 mg ￥280
In-stock
1 g ￥440
In-stock
5 g   询价  
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Other Forms of Perfluoroundecanoic acid:

Perfluoroundecanoic acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation[1][2][3][4].

体外研究
(In Vitro)

Perfluoroundecanoic acid (2-16 μM，24 小时) 通过增加 M2 标志物 (ARG1、CD163、TGF-β) 的蛋白和 mRNA 水平以及降低 M1 标志物 (iNOS) 的水平，促进 RAW264.7 巨噬细胞的 M2 极化[1]。
Perfluoroundecanoic acid (8 μM，24 小时) 在 RAW264.7 细胞中激活 Wnt/β-catenin 通路，增强 β-catenin 的表达和核转位[1]。
Perfluoroundecanoic acid (8 μM，24 小时) 预处理的 RAW264.7 细胞条件培养基促进 A2780 和 SKOV3 卵巢癌细胞的迁移和侵袭，这一作用可被 β-catenin 抑制剂 ICG001 (HY-14428) 逆转[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Perfluoroundecanoic acid 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 2, 4, 8, 16 μM
Incubation Time: 24 h
Result: Increased protein levels of M2 markers (ARG1, CD163) and decreased M1 marker (iNOS), with the most significant changes at 8 μM.
Increased β-catenin protein level and nuclear translocation; no significant changes in p-smad2, p-smad3, p-Akt, p-mTOR, or PPARα.
体内研究
(In Vivo)

Perfluoroundecanoic acid (8 μM 预处理的 RAW264.7 细胞，与 SKOV3 细胞一起腹腔内共同注射，持续 4 周) 增加 BALB/c 裸鼠卵巢癌转移结节的数量和重量[1]。
Perfluoroundecanoic acid (0-10 mg/kg，口服，每日一次，21-35 天) 通过氧化应激和自噬抑制青春期雄性 Sprague-Dawley 大鼠的 Leydig 细胞发育和功能[2]。
Perfluoroundecanoic acid (3-300 μg/L，饮用水中，从交配到妊娠、哺乳直至 30 周龄) 加速 1 型糖尿病小鼠中胰岛炎的发展[3]。
Perfluoroundecanoic acid (0.1-1.0 mg/kg，每天口服，28-35 天) 通过氧化应激诱导雄性 Swiss 小鼠的 DNA 损伤、生殖和病理生理功能障碍[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-week-old female BALB/c nude mice were intraperitoneally coinjected pretreated RAW264.7 cells and SKOV3 cells, with observation for 4 weeks[1]
Dosage: 8 μM pretreated RAW264.7 cells
Administration: Co-injected intraperitoneally with SKOV3 cells for 4 weeks
Result: Increased the number and weight of ovarian cancer metastatic nodules.
Reduced the number and weight of ovarian cancer metastatic nodules in the above mouse model when pretreated with β-catenin inhibitor ICG001.
Animal Model: 35 days old Sprague-Dawley rats[2]
Dosage: 1, 5, 10 mg/kg
Administration: p.o. daily for 21-35 days
Result: Reduced serum testosterone at ≥1 mg/kg; no effect on serum estradiol.
Reduced serum LH at ≥1 mg/kg and serum FSH at 5 and 10 mg/kg.
Down-regulated expression of Lhb and Fshb in the pituitary at 5 and/or 10 mg/kg; up-regulated Gnrhr expression at 10 mg/kg.
Reduced Leydig cell number (CYP11A1-positive and HSD11B1-positive) at 5 and 10 mg/kg; no effect on Sertoli cell number.
Down-regulated expression of steroidogenesis-related genes (Lhcgr, Scarb1, Star, Cyp11a1) and their proteins in the testis at various doses.
Reduced sperm in the epididymis caput, corpus, and cauda at 10 mg/kg.
Increased testicular triglyceride levels at 5 and 10 mg/kg; no effect on testicular total cholesterol.
Down-regulated expression of Sod1 and Sod2 in the testis at various doses; increased MDA levels at 10 mg/kg.
Increased LC3B and p62 levels.
Reduced Beclin1 at 5 and 10 mg/kg.
Reduced phosphorylation of mTOR, AKT1, AKT2, and ERK1/2.
Reduced BCL2 levels at 5 and 10 mg/kg; increased BAX level at 10 mg/kg.
Animal Model: Female non-obese diabetic (NOD) mice (offspring of 8-week-old females and 10-week-old males)[3]
Dosage: 3, 30, 300 μg/L in drinking water
Administration: p.o. from mating through gestation, lactation and until 30 weeks of age
Result: Increased pancreatic insulitis grade at 11 weeks of age (300 μg/L).
Increased number of apoptotic cells in pancreatic islets with insulitis grade 0 at 11 weeks of age (300 μg/L).
Reduced peritoneal macrophage phagocytosis at 7 weeks of age (300 μg/L).
Increased ConA-induced IL-2 secretion and decreased LPS-induced IL-6 secretion in splenocytes at 11 weeks of age (3 μg/L).
Showed a trend of increased ConA-induced IL-6 and IFN-γ secretion in splenocytes at 11 weeks of age (300 μg/L).
Had no significant effect on accelerating diabetes development, and low doses (3, 30 μg/L) tended to reduce diabetes incidence.
Animal Model: Male Swiss mice (8 or 13 weeks old)[4]
Dosage: 0.1, 0.3, 0.5, 0.7, 1.0 mg/kg
Administration: p.o. for 28-35 days
Result: Induced significant hepatic DNA damage.
Caused reproductive toxicity: reduced sperm count and motility, increased sperm abnormalities; elevated serum LH and FSH, reduced testosterone; testicular atrophy and histopathological lesions.
Altered hematological parameters: decreased PCV, Hb, platelets, RBC count and indices; increased WBC and neutrophils.
Disrupted clinical biochemistry: elevated AST, ALT, urea, total cholesterol, triglyceride; reduced ALP, albumin, creatinine, HDL.
Induced oxidative stress in liver and testis: increased SOD, CAT, GST, MDA; reduced GPx, GSH.
Caused histopathological lesions in liver (cellular infiltration, venous congestion) and kidney (interstitial congestion, tubular lumen expansion); no spleen lesions.
分子量

564.09

Formula

C11HF21O2
CAS 号
性状

固体

颜色

White to off-white

中文名称

全氟十一烷酸； 二十一氟十一烷酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 200 mg/mL (354.55 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7728 mL 8.8638 mL 17.7277 mL
5 mM 0.3546 mL 1.7728 mL 3.5455 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
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体积
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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

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体积 (final)

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动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

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由于实验过程有损耗，建议您多配一只动物的量
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工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.85%

COA (284 KB) HNMR (114 KB) CNMR (130 KB) GC (214 KB)

产品使用指南 (1538 KB)
参考文献

Perfluoroundecanoic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7728 mL 8.8638 mL 17.7277 mL 44.3192 mL
5 mM 0.3546 mL 1.7728 mL 3.5455 mL 8.8638 mL
10 mM 0.1773 mL 0.8864 mL 1.7728 mL 4.4319 mL
15 mM 0.1182 mL 0.5909 mL 1.1818 mL 2.9546 mL
20 mM 0.0886 mL 0.4432 mL 0.8864 mL 2.2160 mL
25 mM 0.0709 mL 0.3546 mL 0.7091 mL 1.7728 mL
30 mM 0.0591 mL 0.2955 mL 0.5909 mL 1.4773 mL
40 mM 0.0443 mL 0.2216 mL 0.4432 mL 1.1080 mL
50 mM 0.0355 mL 0.1773 mL 0.3546 mL 0.8864 mL
60 mM 0.0295 mL 0.1477 mL 0.2955 mL 0.7387 mL
80 mM 0.0222 mL 0.1108 mL 0.2216 mL 0.5540 mL
100 mM 0.0177 mL 0.0886 mL 0.1773 mL 0.4432 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perfluoroundecanoic acid2058-94-8全氟十一烷酸 二十一氟十一烷酸Biochemical Assay Reagentsβ-cateninWntArginaseTGF-beta/SmadmTORAktERKAtg8/LC3p62AutophagyBeta cateninTransforming growth factor betaMammalian target of RapamycinPKBProtein kinase BExtracellular signal regulated kinasesAutophagy-related 8Sequestosome-1SQSTM1T1DM DiabetesNOD miceInsulitisovarian cancerinflammation,β-cateninAKTERK.P62Inhibitorinhibitorinhibit

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