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  3. Piperaquine phosphate

Piperaquine phosphate 

目录号: HY-B1896A
产品使用指南

Piperaquine 是一种双喹啉抗疟药,通常作为青蒿素药物组合疗法 (ACT) 的抗疟伴侣。

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Piperaquine phosphate Chemical Structure

Piperaquine phosphate Chemical Structure

CAS No. : 85547-56-4

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Description

Piperaquine is a bisquinoline antimalarial agent, often as a partner antimalarial for artemisinin drug-based combination therapy (ACT)[1][2].

In Vivo

Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1].

Animal Model: Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1]
Dosage: 0, 10, 30, 90 mg/kg
Administration: A single i.p. administration
Result: The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg.
All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
Animal Model: Male Swiss mice (6 weeks old)[1]
Dosage: 90 mg/kg (Pharmacokinetic Analysis)
Administration: A single i.p. administration
Result: t1/2=17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.
Molecular Weight

633.51

Formula

C₂₉H₃₅Cl₂N₆O₄P

CAS No.

85547-56-4

中文名称

磷酸哌喹

SMILES

ClC1=CC=C2C(N3CCN(CCCN4CCN(C5=CC=NC6=CC(Cl)=CC=C56)CC4)CC3)=CC=NC2=C1.O=P(O)(O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PiperaquineParasiteantimalarialartemisinindrug-basedcombinationtherapyACTInhibitorinhibitorinhibit

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