2. Anti-infection
  3. Bacterial
  4. Plaunotol

Plaunotol 是一种口服有效的无环二萜醇。Plaunotol 对导致消化性溃疡的幽门螺杆菌具有抗菌活性。Plaunotol 抑制肿瘤血管生成和细胞的增殖活性。Plaunotol 依赖半胱天冬蛋白酶-8 和半胱天冬蛋白酶-9 途径的激活诱导细胞凋亡 (apoptosis) 。Plaunotol 可作为一种潜在的抗结肠癌的抗癌剂。

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Plaunotol Chemical Structure

Plaunotol Chemical Structure

CAS No. : 64218-02-6

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Plaunotol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Plaunotol is an orally active acyclic diterpene alcohol. Plaunotol has antibacterial activity against Helicobacter pylori which causes peptic ulcer [1]. Plaunotol inhibits tumor angiogenesis and cell proliferation. Plaunotol induces apoptosis by activation of caspase 8 and caspase 9 pathways. Plaunotol is a potential anticancer agent against colon cancer [2].

体外研究
(In Vitro)

Plaunotol (0, 10, 20 或 40 μM, 24 或 48 h) 对人结肠癌细胞系 DLD1 细胞增殖有显著抑制作用[2]。
Plaunotol (40 μM, 24 或 48 h) 诱导人结肠癌细胞系 DLD1 细胞凋亡[2]。
Plaunotol (0, 10, 20 或 40 μM, 48 h) 可激活人结肠癌细胞系 DLD1 中的半胱天冬蛋白酶-3[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Plaunotol 相关抗体:

Cell Proliferation Assay[2]

Cell Line: human colon cancer cell line DLD1
Concentration: 0, 10, 20, or 40 μM
Incubation Time: 24 or 48 h
Result: Inhibited the proliferation of human colon cancer cell line DLD1 after 48 h.

Apoptosis Analysis[2]

Cell Line: human colon cancer cell line DLD1
Concentration: 40 μM
Incubation Time: 24 or 48 h
Result: Caused a significant increase in the population of Annexin V [+] apoptotic cells.

Western Blot Analysis[2]

Cell Line: human colon cancer cell line DLD1
Concentration: 40 μM
Incubation Time: 48 h
Result: Induced PARP cleavage, and showed activation of caspase-3.
体内研究
(In Vivo)

Plaunotol (10, 25 或 50 mg/kg, 口服, 3 h) 在经 C48/80 处理雄性维斯塔大鼠中具有显著减轻其胃粘膜损伤程度的作用[3]。
Plaunotol (10, 25 或 50 mg/kg, 口服, 3 h) 在经 C48/80 处理雄性维斯塔大鼠中不会影响血清血清素、组胺浓度以及胃粘膜血流量[3]。
Plaunotol (10, 25 或 50 mg/kg, 口服, 3 h) 在经 C48/80 处理雄性维斯塔大鼠中显著减弱了胃粘膜髓过氧化物酶 (MPO) 活性和脂质过氧化物硫代巴比妥酸反应物质 (TBARS) 含量[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[3]
Dosage: 10, 25 or 50 mg/kg
Administration: Oral administration
Result: Plaunotol attenuated the severity of the gastric mucosal lesions.
分子量

306.48

Formula

C20H34O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Plaunotol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Plaunotol64218-02-6CS-684CS684CS 684Bacterialorally activetopical applicationhuman colon cancer cell line DLD1antigastritiscolon cancerInhibitorinhibitorinhibit

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