Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed)  (Synonyms: PVA (Mw 30000-70000, 87-90% hydrolyzed); Poly(Ethenol) (Mw 30000-70000, 87-90% hydrolyzed))

Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 30000-70000 and hydrolytic properties. The degree of hydrolysis refers to the degree to which the acetate groups in the original polyvinyl acetate are converted into hydroxyl groups during the hydrolysis process. Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. A degree of hydrolysis of 87-90% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipients^[1].

Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (Polyvinyl alcohol) 的溶血指数为 0.656% (羊血) 和 0.028% (人血)^[6]。
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (Polyvinyl alcohol) (5 g/25 cm³ 去离子水) 可作为酵母细胞对铜进行生物吸附的细胞固定基质^[7]。
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (Polyvinyl alcohol) (1 mg/mL，14 天) 可替代白血病细胞 (AML) 培养中的血清白蛋白^[8]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (Polyvinyl alcohol) (2000-5000 ppm，饮食，每日，连续两代) 在 Sprague-Dawley 大鼠的亲本动物（P0 和 F1）或 F1 和 F2 后代中均未表现出不良毒理学或生殖影响^[2]。
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (^14C 标记的 Polyvinyl alcohol，3 mg/kg，每日) 在 Fischer 344 大鼠中表现出阴道吸收^[3]。
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (Polyvinyl alcohol) 显示出最佳粘度范围，在兔子中的最佳粘度为 12-15 cps^[4]。
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (Polyvinyl alcohol) (1 mL/天，皮下注射，Gentamicin (HY-A0276A) 前 21 天) 在大鼠中诱导对 Gentamicin 肾毒性的早期敏感性^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

30000-70000 (Approximately)

(C₂H₄O)x

9002-89-5

固体

White to off-white

聚乙烯醇 (Mw 30000-70000, 87-90% hydrolyzed)

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Elsherbiny DA, et al. Self-crosslinked polyvinyl alcohol/cellulose nanofibril cryogels loaded with synthesized aminophosphonates as antimicrobial wound dressings. J Mater Chem B. 2023 Aug 2;11(30):7144-7159.  [Content Brief]

  [2]. Rodwell DE, et al. Effects of polyvinyl alcohol administered in the diet to rats on fertility, early embryonic development, growth and development. Food Chem Toxicol. 2003 May;41(5):729-37.  [Content Brief]

  [3]. Sanders JM, et al. Vaginal absorption of polyvinyl alcohol in Fischer 344 rats. Hum Exp Toxicol. 1990 Mar;9(2):71-7.  [Content Brief]

  [4]. Patton TF, et al. Ocular evaluation of polyvinyl alcohol vehicle in rabbits. J Pharm Sci. 1975 Aug;64(8):1312-6.  [Content Brief]

  [5]. Carver MP, et al. Dose-response studies of gentamicin nephrotoxicity in rats with experimental renal dysfunction. II. Polyvinyl alcohol glomerulopathy. Toxicol Appl Pharmacol. 1985 Sep 15;80(2):264-73. doi: 10.1016/0041-008x(85)90083-3.  [Content Brief]

  [6]. Alexandre N, et al. Biocompatibility and hemocompatibility of polyvinyl alcohol hydrogel used for vascular grafting--In vitro and in vivo studies. J Biomed Mater Res A. 2014 Dec;102(12):4262-75.  [Content Brief]

  [7]. Ting Y P, et al. Use of polyvinyl alcohol as a cell immobilization matrix for copper biosorption by yeast cells. Journal of Chemical Technology & Biotechnology: International Research in Process, Environmental & Clean Technology, 2000, 75(7): 541-546.

  [8]. Nishimura T, et al. Use of polyvinyl alcohol for chimeric antigen receptor T-cell expansion. Exp Hematol. 2019 Dec;80:16-20.  [Content Brief]