2. PROTAC Protein Tyrosine Kinase/RTK Apoptosis Stem Cell/Wnt JAK/STAT Signaling
  3. PROTACs c-Met/HGFR Apoptosis STAT
  4. PROTAC c-Met degrader-5

PROTAC c-Met degrader-5 (Compound D19) 是一种具有口服活性的 c-Met PROTAC 降解剂，其在 EBC-1 和 Hs746T 细胞中的 DC50 分别为 0.42 nM 和 0.32 nM。PROTAC c-Met degrader-5 显著诱导细胞凋亡 (apoptosis)、G1 细胞周期阻滞，并抑制细胞迁移和侵袭。PROTAC c-Met degrader-5 对 c-Met 依赖性癌细胞和 Tepotinib (HY-14721) 耐药性癌细胞具有强效的抗增殖和降解作用。粉色：c-Met ligand (HY-W425461)；蓝色：CRBN ligase ligand (HY-14658)；黑色：linker

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PROTAC c-Met degrader-5

PROTAC c-Met degrader-5 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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PROTAC c-Met degrader-5 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC c-Met degrader-5 (Compound D19) is an orally active c-Met PROTAC degrader with DC50s of 0.42 and 0.32 nM in EBC-1 and Hs746T cells, respectively. PROTAC c-Met degrader-5 significantly induces cell apoptosis, G1 cell cycle arrest, and inhibits cell migration and invasion. PROTAC c-Met degrader-5 has potent antiproliferative and degradation efficacy against c-Met-addicted cancer cells and Tepotinib (HY-14721)-resistant cancer cells[1]. Pink: c-Met ligand (HY-W425461); Blue: CRBN ligase ligand (HY-14658); Black: linker

IC50 & Target[1]

p-STAT3

 

体内研究
(In Vivo)

PROTAC c-Met degrader-5 (5-10 mg/kg，口服，每日一次，持续 18 天) 可强效抑制 EBC-1 异种移植小鼠模型中的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

846.93

Formula

C47H46N10O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC c-Met degrader-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC c-Met degrader-5PROTACsc-Met/HGFRApoptosisSTATPROTACDegradationc-MetAntiproliferativeTepotinib-resistantCancerEBC-1 xenograft mice modelEBC-1 cellsHs746T cellsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-175320
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