2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. PVD-06

PVD-06 是选择性 PTPN2 降解剂 (PTPN2/PTP1B 选择性指数 >60 倍)，以泛素化和蛋白酶体依赖性方式诱导 PTPN2 降解。PVD-06 可促进 T 细胞活化，并放大 IFN-γ 介导的细胞毒性。PVD-06 具有抗癌活性。

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PVD-06 Chemical Structure

PVD-06 Chemical Structure

CAS No. : 3032975-48-4

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PVD-06 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PVD-06 is a selective PTPN2 degrader (PTPN2/PTP1B selectivity index >60-fold) and induces PTPN2 degradation in a ubiquitination- and proteasome-dependent manner. PVD-06 promotes T cell activation and amplifies IFN-γ-mediated cytotoxicity. PVD-06 has anticancer activity[1].

IC50 & Target

PTPN2[1]
分子量

1074.13

Formula

C48H55F4N9O11S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PVD-06 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PVD-063032975-48-4PVD06PVD 06Phosphataseubiquitinationproteasome-dependent degradationT cell activationIFN-γInhibitorinhibitorinhibit

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目录号：
HY-149760
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