2. Epigenetics
  3. Epigenetic Reader Domain
  4. QA-68

QA-68 (QA-68-ZU81) 是一种有效的 BRD9 降解剂。QA-68 能抑制细胞周期进程和细胞集落形成。QA-68 对急性髓系白血病 (AML) 细胞系具有抗增殖活性。

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QA-68 Chemical Structure

QA-68 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

QA-68 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

QA-68 (QA-68-ZU81) is a potent bromodomain-containing protein 9 (BRD9) degrader. QA-68 can inhibit cell cycle progression and cell colony formation. QA-68 has antiproliferative activity against acute myeloid leukemia (AML) cell lines[1]. QA-68 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

BRD9

 

体外研究
(In Vitro)

QA-68 (0-1000 nM; 24 h) exhibits antiproliferative activity against MV4-11, SKM-1 and Kasumi-1-luc+ cells, and inhibits BRD9 protein expression in MV4-11, SKM-1, SEM, NALM6, RS4;11[1].
QA-68 (0.1-1000 nM; 4 days) effectively inhibits SKM-1 cell cycle progression[1].
QA-68 (1000 nM; 12 days) inhibits colony formation of additional primary AML bone marrow and PBMC cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

QA-68 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MV4-11, SKM-1 and Kasumi-1-luc+ cells
Concentration: 0-1000 nM
Incubation Time: 24 h
Result: Exhibited concentration-dependent inhibition of proliferation of MV4-11, SKM-1 and Kasumi-1-luc+ cells with IC50s of 1-10 nM in MV4;11 and SKM-1, and IC50 of 10-100 nM in Kasumi-1-luc +, respectively.

Cell Cycle Analysis[1]

Cell Line: SKM-1cells
Concentration: 0.1, 1, 10, 100 and 1000 nM
Incubation Time: 6 days
Result: Effectively inhibited SKM-1 cell cycle progression.

Western Blot Analysis[1]

Cell Line: MV4-11, SKM-1, SEM, NALM6, RS4;11
Concentration: 0, 1, 10, 100 and 1000 nM
Incubation Time: 24 h
Result: Inhibited BRD9 protein in all tested cell lines.
分子量

1169.42

Formula

C61H72N10O10S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

QA-68 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QA-68QA-68-ZU81QA68QA 68Epigenetic Reader Domainacute myeloid leukemiaAMLantiproliferativeMV4-11SKM-1SEMNALM6RS4;11Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-150797
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