1. Others Anti-infection Autophagy
  2. Isotope-Labeled Compounds Reverse Transcriptase HIV Autophagy
  3. (Rac)-Efavirenz-d4

(Rac)-Efavirenz-d4  (Synonyms: 依法韦仑-d4)

目录号: HY-10572BS
产品使用指南

(Rac)-Efavirenz-d4 是 Efavirenz 氘代消旋体。Efavirenz (DMP 266) 是一种有效的野生型 HIV-1 RT 抑制剂,Ki 为 2.93 nM,抑制 HIV-1 复制,IC95 为 1.5 nM。

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(Rac)-Efavirenz-d<sub>4</sub> Chemical Structure

(Rac)-Efavirenz-d4 Chemical Structure

CAS No. : 1246812-58-7

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  • 生物活性

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生物活性

(Rac)-Efavirenz-d4 is a labelled racemic Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1]. (Rac)-Efavirenz-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

319.70

Formula

C14H5D4ClF3NO2

CAS 号
中文名称

依法韦仑-d4;施多宁-d4;依法韦伦-d4;依法维仑-d4;依氟维纶-d4;依非韦伦-d4;艾法韦仑-d4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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