ABCA2 蛋白, Human (HEK293, His, Strep, Flag)

ABCA2 Protein, Human (HEK293, His, Strep, Flag) is the recombinant human-derived ABCA2, expressed by HEK293, with Strep, His, Flag labeled tag.

ABCA2 是一种可能的脂质转运蛋白，通过调节细胞内鞘脂代谢来调节晚期内体/溶酶体中的胆固醇隔离，从而参与胆固醇稳态。它可能改变内膜脂双层中神经酰胺的跨膜分布，促进其保留在外叶，从而增加晚期内体/溶酶体中的酸性神经酰胺酶活性，促进神经酰胺脱酰基化为鞘氨醇，导致游离胆固醇在溶酶体中的隔离。此外，ABCA2 通过调节鞘脂代谢激活信号通路来调节淀粉样前体蛋白的转录，或通过其在 APP 的 γ-分泌酶加工中的作用来调节淀粉样 β 的产生。可能参与髓鞘形成（By similarity）。

Human

HEK293

N-His;C-Flag;N-StrepⅡ

Q9BZC7-1 (G2-C2435)

20

Partial

Greater than 85% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.22 μm filtered solution of 50 mM HEPES (pH 7.5), 150 mM NaCl, 0.04% (w/v) GDN, 0.0002% (w/v) CHS,cOmplete Protease Inhibitor Tablet.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.