Animal-Free FGF-20 蛋白, Human (His)

FGF-20 protein, a homodimer, functions as a neurotrophic factor essential for regulating central nervous system development and function. It interacts with specific receptors, FGFR2 and FGFR4, with heparan sulfate glycosaminoglycans enhancing the binding affinity between fibroblast growth factors (FGFs) and their receptors, serving as coreceptors in this intricate signaling process. Animal-Free FGF-20 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-20 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free FGF-20 Protein, Human (His) is 209 a.a., with molecular weight of ~24.24 kDa.

FGF-20 蛋白是一种神经营养因子，对于调节中枢神经系统发育和功能至关重要。它作为同型二聚体起作用，与特定受体（即 FGFR2 和 FGFR4）相互作用。硫酸乙酰肝素糖胺聚糖增强了成纤维细胞生长因子 (FGF) 与其受体之间的结合亲和力，在这一复杂的信号传导过程中充当辅助受体。

The ED₅₀ is 1.3-3.2 ng/mL as measure by its ability to induce 3T3 cells proliferation, corresponding to a specific activity of recombinant human FGF-20 is > 2 x 10⁵ IU/mg.

Human

E. coli

C-His

Q9NP95 (P3-T211)

26281  [NCBI]

MPLAEVGGFLGGLEGLGQQVGSHFLLPPAGERPPLLGERRSAAERSARGGPGAAQLAHLHGILRRRQLYCRTGFHLQILPDGSVQGTRQDHSLFGILEFISVAVGLVSIRGVDSGLYLGMNDKGELYGSEKLTSECIFREQFEENWYNTYSSNIYKHGDTGRRYFVALNKDGTPRDGARSKRHQKFTHFLPRPVDPERVPELYKDLLMYT

Approximately 24.24 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 8.0.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.