2. Gene
  3. FGF20 - fibroblast growth factor 20 Gene

FGF20 - fibroblast growth factor 20 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：成纤维细胞生长因子 20

种属: Homo sapiens

同用名: RHDA2; FGF-20

基因 ID: 26281 | 基因类型: protein coding

关于 FGF20

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:16,992,181-17,002,345 (from NCBI)

This gene has 2 transcripts (splice variants), 265 orthologues, 21 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是成纤维细胞生长因子家族的一员。成纤维细胞生长因子具有广泛的促有丝分裂和细胞存活活性，并参与多种生物过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。该基因产物是一种分泌性神经营养因子，但缺乏典型的信号肽。它在正常大脑中表达，特别是小脑，并可能调节中枢神经系统的发育和功能。该蛋白质的同二聚化显示可调节其受体结合活性和细胞外基质中的浓度梯度。该基因的遗传变异与帕金森病易感性有关。[RefSeq 提供，2009 年 10 月]

The protein encoded by this gene is a member of the Fibroblast Growth Factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]

FGF20 基因产物(1)

mRNA Protein Name
NM_019851.3 NP_062825.1 fibroblast growth factor 20

FGF20 蛋白结构

FGF

FGF: Fibroblast growth factor (65 - 191)

  • 0
  • 100
  • 211 a.a.
蛋白主名 其他名称

fibroblast growth factor 20

重组 FGF20 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700062AF Animal-Free FGF-20 Protein, Human (His) Q9NP95 (P3-T211) ≥95%

关联疾病

疾病名称 别名
Renal Hypodysplasia/Aplasia 2

RHDA2

Hypodysplasia/Aplasia, Renal, Type 2
Renal Agenesis, Bilateral

Bilateral Renal Agenesis
Bilateral Renal Aplasia
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Potter'S Syndrome

Potter Sequence

Potter Syndrome

Oligohydramnios Sequence

Congenital Absence Of Kidneys Syndrome
Townes-Brocks Syndrome

Townes Syndrome

Renal-Ear-Anal-Radial Syndrome

Anus, Imperforate, With Hand, Foot And Ear Anomalies

Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome

Rear Syndrome

Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs

Tbs

Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs

Imperforate Anus With Hand, Foot And Ear Anomalies

Anal-Ear-Renal-Radial Malformation Syndrome

Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome

Imperforate Anus-Hand And Foot Anomalies Syndrome

Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome

Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs
Renal Hypodysplasia/Aplasia 1

Renal Agenesis

Renal Adysplasia

Renal Aplasia

RHDA1

Hereditary Renal Aplasia

Hra

Hereditary Urogenital Adysplasia

Hypodysplasia/Aplasia, Renal, Type 1

Congenital Absence Of Kidneys Syndrome

Congenital Absence Of Kidney

Aplastic Kidney
Cakut

Renal Or Urinary Tract Malformation

Congenital Anomalies Of Kidney And Urinary Tract

Congenital Anomaly Of Kidney And Urinary Tract

Congenital Anomalies Of The Kidney And Urinary Tract

Kidney And Urinary Tract, Anomalies, Congenital

Renal Hypodysplasia, Nonsyndromic, 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04897 FGF20 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FGF20 VGNC VGNC:104454
Felis catus FGF20 VGNC VGNC:107333
Mus musculus FGF20 MGD MGI:1891346
Rattus norvegicus FGF20 RGD RGD:71068
Canis familiaris FGF20 VGNC VGNC:51802
Bos taurus FGF20 VGNC VGNC:28976
Others FGF20 NCBI
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