ATP2A1 蛋白, Human (Cell-Free, His)

ATP2A1 is critical for striated muscle function, acting as the primary Ca(2+) ATPase to efficiently reuptake cytosolic Ca(2+) into the sarcoplasmic reticulum. Through ATP hydrolysis, ATP2A1 transfers calcium from the cytoplasm to the sarcoplasmic reticulum lumen, which is critical for precise control of calcium levels, regulation of isolation, and control of muscle excitation and contraction dynamics. ATP2A1 Protein, Human (Cell-Free, His) is the recombinant human-derived ATP2A1 protein, expressed by E. coli Cell-free, with N-10*His labeled tag.

ATP2A1 是横纹肌功能的关键参与者，作为主要的 Ca(2+) ATP 酶，负责将胞质 Ca(2+) 有效再摄取到肌浆网中。ATP2A1 通过 ATP 的水解作用，促进钙从细胞质转移到肌浆网腔，这一过程对于调节钙封存以及肌肉兴奋和收缩的复杂动力学至关重要。这种复杂的分子机制凸显了 ATP2A1 在协调肌肉细胞内钙水平的精确控制中不可或缺的作用，最终有助于横纹肌的整体性能和功能。

Human

E. coli Cell-free

N-10*His

O14983 (E10-E450)

784

Partial

EECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDKPVRPGQYDGLVELATICALCNDSSLDFNEAKGVYEKVGEATETALTTLVE

Approximately 50 kDa,based on SDS-PAGE under reducing conditions.

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.