2. 重组蛋白
  3. CD Antigens
  4. B Cell CD Proteins Macrophage CD Proteins Monocyte CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins
  5. CD147
  6. Basigin/CD147 蛋白, Mouse (209a.a, HEK293, His)

Basigin/CD147 蛋白, Mouse (209a.a, HEK293, His)

目录号: HY-P75481
COA 产品使用指南

Basigin/CD147 蛋白对于视网膜成熟和发育至关重要，作为 NXNL1 受体促进视网膜锥体感光细胞的存活。Basigin/CD147 蛋白, Mouse (209a.a, HEK293, His) 是重组的 Basigin/CD147 蛋白，由 HEK293 表达，带有 C-His 标签。Basigin/CD147 蛋白, Mouse (209a.a, HEK293, His) 全长 209 个氨基酸，分子量为 30-35 kDa。

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描述

The Basigin/CD147 protein is essential for retinal maturation and development, acting as a NXNL1 receptor to promote the survival of retinal cone photoreceptor cells. Basigin/CD147 Protein, Mouse (209a.a, HEK293, His) is the recombinant mouse-derived Basigin/CD147 protein, expressed by HEK293 , with C-His labeled tag. The total length of Basigin/CD147 Protein, Mouse (209a.a, HEK293, His) is 209 a.a., with molecular weight of 30-35 kDa.
研究背景

Basigin/CD147 蛋白对于正常视网膜成熟和发育是不可或缺的，作为 NXNL1 的关键细胞表面受体，对 NXNL1 介导的视网膜锥光感受器的存活做出显着贡献。Basigin/CD147 与葡萄糖转运蛋白 SLC16A1/GLUT1 和 NXNL1 合作，通过增强有氧糖酵解和促进葡萄糖进入光感受器来促进视网膜锥体存活。它作为亲环蛋白的信号传导受体，在与免疫细胞趋化和粘附相关的 PPIA/CYPA 和 PPIB/CYPB 依赖性信号传导中发挥重要作用。此外，Basigin/CD147 在将单羧酸转运蛋白 SLC16A1、SLC16A3 和 SLC16A8 靶向质膜方面发挥着关键作用。作为内皮细胞中血管内皮生长因子受体 2 (KDR/VEGFR2) 的辅助受体，它增强 VEGFA 介导的激活和下游信号传导，通过 EPAS1/HIF2A 介导的 VEGFA 和 KDR/VEGFR2 上调促进血管生成。此外，Basigin/CD147 在精子发生中发挥着至关重要的作用，介导生殖细胞和支持细胞之间的相互作用，并被证明对于生殖细胞发育和分化为圆形精子细胞至关重要。
种属

Mouse
表达系统

HEK293
标签

C-His
蛋白编号

P18572 (M1-R209)
基因 ID

12215  [NCBI]
蛋白结构
N-term
Basigin (M1-R209)
Accession # P18572
His
C-term
同用名
Basigin; HT7 antigen; Membrane glycoprotein gp42; Bsg
分子量

30-35 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE
性状

溶液
组分

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.
复溶方法

N/A.
保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.
文件资料

COA (209 KB)

产品使用指南 (1213 KB)

Basigin/CD147 Protein, Mouse (209a.a, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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