Calnexin 蛋白, Mouse (HEK293, His)

Calnexin protein, a calcium-binding chaperone located in the endoplasmic reticulum (ER), plays a pivotal role in interacting with newly synthesized monoglucosylated glycoproteins, contributing to protein assembly and retention of unassembled protein subunits within the ER. With a key function in the ER's quality control apparatus, calnexin participates in the retention of incorrectly folded proteins. Notably, it associates with partial T-cell antigen receptor complexes in immature thymocytes, suggesting a role in signaling and regulation of thymocyte maturation. Additionally, calnexin may be involved in receptor-mediated endocytosis at the synapse. Its interactions extend to various proteins, including MAPK3/ERK1, KCNH2, SERPINA2P/SERPINA2, SGIP1, PPIB, SMIM22, TMX2, TMEM35A/NACHO, CHRNA7, RETREG2, RETREG3, DNM1L, and ADAM7, highlighting its versatility in forming complexes and participating in diverse cellular processes. The palmitoylated form specifically interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins and emphasizing its role in protein maturation within the ER. Calnexin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Calnexin protein, expressed by HEK293 , with C-His labeled tag. The total length of Calnexin Protein, Mouse (HEK293, His) is 482 a.a., with molecular weight of ~53.9 kDa.

钙连接蛋白是一种位于内质网 (ER) 中的钙结合伴侣，在与新合成的单葡萄糖基化糖蛋白相互作用中发挥着关键作用，有助于蛋白质组装和未组装蛋白质亚基在 ER 内的保留。钙连接蛋白在 ER 质量控制装置中发挥着关键作用，参与保留错误折叠的蛋白质。值得注意的是，它与未成熟胸腺细胞中的部分 T 细胞抗原受体复合物相关，表明在胸腺细胞成熟的信号传导和调节中发挥作用。此外，钙连接蛋白可能参与突触受体介导的内吞作用。其相互作用扩展到多种蛋白质，包括 MAPK3/ERK1、KCNH2、SERPINA2P/SERPINA2、SGIP1、PPIB、SMIM22、TMX2、TMEM35A/NACHO、CHRNA7、RETREG2、RETREG3、DNM1L 和 ADAM7，突出了其在形成复合物和参与不同的细胞过程。棕榈酰化形式与核糖体易位子复合物成分 SSR1 特异性相互作用，促进糖蛋白的有效折叠并强调其在内质网内蛋白质成熟中的作用。

Mouse

HEK293

C-His

P35564 (M1-P482)

12330  [NCBI]

Approximately 53.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.