CD146/MCAM 蛋白, Human (HEK293, His)

The CD146/MCAM protein is critical for maintaining endothelial monolayer integrity and cell adhesion in vascular tissue. Its expression promotes the interaction of melanoma cells with the vasculature and may contribute to tumor spread through the bloodstream. CD146/MCAM Protein, Human (HEK293, His) is the recombinant human-derived CD146/MCAM protein, expressed by HEK293 , with C-His labeled tag. The total length of CD146/MCAM Protein, Human (HEK293, His) is 536 a.a., with molecular weight (glycosylation form) of 80-110 kDa.

CD146/MCAM 蛋白在细胞粘附和维持血管组织细胞间连接处内皮单层的完整性中发挥着至关重要的作用。它的表达使黑色素瘤细胞能够与血管系统的细胞成分相互作用，从而可能促进肿瘤通过血流的扩散。在胚胎发育过程中，CD146/MCAM 可能充当神经嵴细胞中的粘附分子。它作为表面受体，启动 FYN 和 PTK2/FAK1 的酪氨酸磷酸化，并导致细胞内钙水平短暂升高。

Human

HEK293

C-His

P43121 (V24-G559)

4162  [NCBI]

80-110 kDa (glycosylation)

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.